Cell apoptosis induced by carcinogenic metals

F. Chen, V. Vallyathan, V. Castranova, X. Shi

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalMolecular and Cellular Biochemistry
Issue number1-2
StatePublished - 2001

Bibliographical note

Funding Information:
Fei Chen was supported by a Career Development Award in Genetics under a cooperative agreement from the Centers for Disease Control and Prevention through the Association of Teachers of Preventive Medicine.

Copyright 2008 Elsevier B.V., All rights reserved.


  • Apoptosis
  • Carcinogenesis
  • DNA damage
  • Metal
  • ROS

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology


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