Abstract
Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 183-188 |
| Number of pages | 6 |
| Journal | Molecular and Cellular Biochemistry |
| Volume | 222 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 2001 |
Bibliographical note
Funding Information:Fei Chen was supported by a Career Development Award in Genetics under a cooperative agreement from the Centers for Disease Control and Prevention through the Association of Teachers of Preventive Medicine.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
Funding
Fei Chen was supported by a Career Development Award in Genetics under a cooperative agreement from the Centers for Disease Control and Prevention through the Association of Teachers of Preventive Medicine.
| Funders | Funder number |
|---|---|
| Centers for Disease Control and Prevention |
Keywords
- Apoptosis
- Carcinogenesis
- DNA damage
- Metal
- ROS
ASJC Scopus subject areas
- Molecular Biology
- Clinical Biochemistry
- Cell Biology
