Cell death genes in invertebrates and (maybe) vertebrates

Robert S. Freeman, Steven Estus, Kazuhiko Horigome, Eugene M. Johnson

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


That naturally occurring cell death in the nervous and other systems is an active and physiologically appropriate process has received much attention recently and has gained a significant degree of acceptance. The identification of cell death genes in invertebrates, the characterization of gene products that function as cell death suppressors, and the demonstration that some proto-oncogenes elicit cell death, as well as proliferation, in certain cell types have heightened interest in the mechanism of programmed cell death. Yet, evidence for a genetic program for cell death in vertebrates remains circumstantial and, so far, vertebrate 'cell death' genes exist only in theory.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number1
StatePublished - Feb 1993

Bibliographical note

Funding Information:
We thank PA Osborne for excellent editorial assistance in preparing this manuscript. We gratefully acknowledge support from NIH postdoctoral training grants NS07071 (RS Freeman) and HL07275 (S Estus), and an NIH postdoctoral fellowship NS09294 (RS Freeman).

ASJC Scopus subject areas

  • General Neuroscience


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