Cell-derived vesicles for in vitro and in vivo targeted therapeutic delivery

Aaron A. Snell, Khaga R. Neupane, J. Robert Mccorkle, Xu Fu, Faruk H. Moonschi, Elizabeth B. Caudill, Jill Kolesar, Christopher I. Richards

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Efficient delivery of therapeutics across the cell membrane to the interior of the cell remains a challenge both in vitro and in vivo. Here, we demonstrate that vesicles derived from cellular membranes can be efficiently loaded with cargo that can then be delivered to the interior of the cell. These vesicles demonstrated cell-targeting specificity as well as the ability to deliver a wide range of different cargos. We utilized this approach to deliver both lipophilic and hydrophilic cargos including therapeutics and DNA in vitro. We further demonstrated in vivo targeting and delivery using fluorescently labeled vesicles to target tumor xenografts in an animal. Cell-derived vesicles can be generated in high yields and are easily loaded with a variety of cargos. The ability of these vesicles to specifically target the same cell type from which they originated provides an efficient means of delivering cargo, such as therapeutics, both in vitro and in vivo.

Original languageEnglish
Pages (from-to)12657-12664
Number of pages8
JournalACS Omega
Volume4
Issue number7
DOIs
StatePublished - Jul 24 2019

Bibliographical note

Publisher Copyright:
© 2019 American Chemical Society.

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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