TY - JOUR
T1 - Cellular localization of responses to catecholamines in brain tissue
AU - Stone, E. A.
AU - Bing, G.
AU - John, S. M.
AU - Zhang, Y.
AU - Filer, D.
N1 - Funding Information:
Supported in part by grants MH45265, MH08618 and AFOSR 89-0208.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The chapter discusses biochemical responses in an attempt to shed light on functional biochemical target cells with β-adrenoceptors. There are two types of target cells with these receptors. The first type is a glial cell in which cAMP is formed, and the second type is a neuron in which the immediate early genes are activated. These two target cells and their possible relationship are discussed. The extent to which the toxin lowers the β-CAMP response is used as a measure of the extent to which β-receptors have a glial localization. The chapter also describes the cellular localization of immediate early gene responses to β- receptor activation in the brain to see if this agrees with the localization of the β-CAMP response. Immediate early genes (IEGs) are a group of genes that are rapidly activated by various neurotransmitters, hormones, and growth factors. It was found that release of the brain norepinephrine (NE) onto β-receptors by the α2-blocker, yohimbine (which antagonizes the inhibition of NE release by α2-agonists), caused cells in many regions of the brain to stain positively for c-fos.
AB - The chapter discusses biochemical responses in an attempt to shed light on functional biochemical target cells with β-adrenoceptors. There are two types of target cells with these receptors. The first type is a glial cell in which cAMP is formed, and the second type is a neuron in which the immediate early genes are activated. These two target cells and their possible relationship are discussed. The extent to which the toxin lowers the β-CAMP response is used as a measure of the extent to which β-receptors have a glial localization. The chapter also describes the cellular localization of immediate early gene responses to β- receptor activation in the brain to see if this agrees with the localization of the β-CAMP response. Immediate early genes (IEGs) are a group of genes that are rapidly activated by various neurotransmitters, hormones, and growth factors. It was found that release of the brain norepinephrine (NE) onto β-receptors by the α2-blocker, yohimbine (which antagonizes the inhibition of NE release by α2-agonists), caused cells in many regions of the brain to stain positively for c-fos.
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U2 - 10.1016/S0079-6123(08)61759-8
DO - 10.1016/S0079-6123(08)61759-8
M3 - Article
C2 - 1337613
AN - SCOPUS:0027102878
SN - 0079-6123
VL - 94
SP - 303
EP - 307
JO - Progress in Brain Research
JF - Progress in Brain Research
IS - C
ER -