The chapter discusses biochemical responses in an attempt to shed light on functional biochemical target cells with β-adrenoceptors. There are two types of target cells with these receptors. The first type is a glial cell in which cAMP is formed, and the second type is a neuron in which the immediate early genes are activated. These two target cells and their possible relationship are discussed. The extent to which the toxin lowers the β-CAMP response is used as a measure of the extent to which β-receptors have a glial localization. The chapter also describes the cellular localization of immediate early gene responses to β- receptor activation in the brain to see if this agrees with the localization of the β-CAMP response. Immediate early genes (IEGs) are a group of genes that are rapidly activated by various neurotransmitters, hormones, and growth factors. It was found that release of the brain norepinephrine (NE) onto β-receptors by the α2-blocker, yohimbine (which antagonizes the inhibition of NE release by α2-agonists), caused cells in many regions of the brain to stain positively for c-fos.
|Number of pages||5|
|Journal||Progress in Brain Research|
|State||Published - Jan 1 1992|
Bibliographical noteFunding Information:
Supported in part by grants MH45265, MH08618 and AFOSR 89-0208.
ASJC Scopus subject areas
- Neuroscience (all)