Central hypotensive effects of the α(2a)-adrenergic receptor subtype

Leigh B. MacMillan, Lutz Hein, Marta S. Smith, Michael T. Piascik, Lee E. Limbird

Research output: Contribution to journalArticlepeer-review

453 Scopus citations


α2-Adrenergic receptors (α2ARs) present in the brainstem decrease blood pressure and are targets for clinically effective antihypertensive drugs. The existence of three α2AR subtypes, the lack of subtype-specific ligands, and the cross-reactivity of α2AR agonists with imidazoline receptors has precluded an understanding of the role of individual α2AR subtypes in the hypotensive response. Gene targeting was used to introduce a point mutation into the α(2a)AR subtype in the mouse genome. The hypotensive response to α2AR agonists was lost in the mutant mice, demonstrating that the α(2a)AR subtype plays a principal role in this response.

Original languageEnglish
Pages (from-to)801-803
Number of pages3
Issue number5276
StatePublished - 1996

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Central hypotensive effects of the α(2a)-adrenergic receptor subtype'. Together they form a unique fingerprint.

Cite this