Ceramic-Based Multisite Electrode Arrays for Chronic Single-Neuron Recording

Karen A. Moxon; Steve C. Leiser; Greg A. Gerhardt; Kenneth A. Barbee; John K. Chapin

doi:10.1109/TBME.2003.821037

Ceramic-Based Multisite Electrode Arrays for Chronic Single-Neuron Recording

Karen A. Moxon, Steve C. Leiser, Greg A. Gerhardt, Kenneth A. Barbee, John K. Chapin

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

A method is described for the manufacture of a microelectrode array for chronic, multichannel, single neuron recording. The ceramic-based, multisite electrode array has four recording sites patterned onto a ceramic shaft the size of a single typical microwire electrode. The sites and connecting wires are applied to the ceramic substrate using a reverse photolithographic procedure. Recording sites (22 x 80 μm) are separated by 200 μm along the shaft. A layer of alumina insulation is applied over the whole array (exclusive of recording sites) by ion-beam assisted deposition. These arrays were capable of recording single neuron activity from each of their recording sites for at least three weeks during chronic implantation in the somatosensory cortex of rats, and several sites had recordings that lasted for more than 8 weeks. The vertical arrangement of the recording sites on these electrodes is ideal for simultaneously recording across the different layers of brain areas such as the cerebral cortex and hippocampus in chronic preparations.

Original language	English
Pages (from-to)	647-656
Number of pages	10
Journal	IEEE Transactions on Biomedical Engineering
Volume	51
Issue number	4
DOIs	https://doi.org/10.1109/TBME.2003.821037
State	Published - Apr 2004

Bibliographical note

Funding Information:
Manuscript received July 9, 2002; revised June 25, 2003. The work of K. A. Moxon, S. C. Leiser, and J. K. Chapin was supported in part by the Defense Advanced Research Projects Agency (DARPA) Office of Naval Research (ONR) under Grant N00014–98-1–0679 and in part by the National Institute of Neurological Disorders and Stroke (NINDS) under Grant 1-RO1-NS26722. The work of G. A. Gerhardt was supported in part by the National Science Foudation (NSF) under Grant DBI-9987807 and in part by the National Institute on Drug Abuse (NIDA) under Grant DA14944. Asterisk indicates corresponding author. *K. A. Moxon is with the School of Biomedical Engineering Science and Health System, Drexel University, Philadelphia, PA 19104 USA and also also with the Department of Neurobiology and Anatomy, MCP Hahnemann University, Philadelphia, PA 19104 USA.

Keywords

Chronic implant
Cortical histology
Microelectrode array
Multiple-single neuron recording
Neural recording

ASJC Scopus subject areas

Biomedical Engineering

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10.1109/TBME.2003.821037

Cite this

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abstract = "A method is described for the manufacture of a microelectrode array for chronic, multichannel, single neuron recording. The ceramic-based, multisite electrode array has four recording sites patterned onto a ceramic shaft the size of a single typical microwire electrode. The sites and connecting wires are applied to the ceramic substrate using a reverse photolithographic procedure. Recording sites (22 x 80 μm) are separated by 200 μm along the shaft. A layer of alumina insulation is applied over the whole array (exclusive of recording sites) by ion-beam assisted deposition. These arrays were capable of recording single neuron activity from each of their recording sites for at least three weeks during chronic implantation in the somatosensory cortex of rats, and several sites had recordings that lasted for more than 8 weeks. The vertical arrangement of the recording sites on these electrodes is ideal for simultaneously recording across the different layers of brain areas such as the cerebral cortex and hippocampus in chronic preparations.",

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Ceramic-Based Multisite Electrode Arrays for Chronic Single-Neuron Recording

Abstract

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Keywords

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