Ceramic-based multisite microelectrode array for rapid choline measures in brain tissue

Jason J. Burmeister, Michael Palmer, Greg A. Gerhardt

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


A ceramic-based multisite microelectrode array to measure choline in vivo in brain tissues is described. The microelectrodes were linear to 200μM choline (R2=0.999±0.001) with a detection limit of approximately 0.4μM (S/N of 3) in both single microelectrode and self-referencing amperometric recording modes. The 90% rise time of the sensor was 1.4s, allowing for rapid measures of choline. Good selectivity (>300:1) was observed over interferents such as ascorbic acid, uric acid, and DOPAC in the single microelectrode mode. However, a self-referencing recording mode was needed to remove potassium-evoked dopamine signals in rat striatum. In vivo measurements of choline in the rat brain are presented.

Original languageEnglish
Pages (from-to)65-74
Number of pages10
JournalAnalytica Chimica Acta
Issue number1
StatePublished - Mar 28 2003

Bibliographical note

Funding Information:
This work is supported by grants NSF (DBI 9987807), (AA11465), NIMH (MH-01245), and NIDA (DA14944).


  • Biosensor
  • CNS
  • Choline
  • Neurotransmitters
  • Voltammetry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy


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