Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

9 Scopus citations


Recent studies show that bioactive lipids are important regulators for stem cell survival and differentiation. The sphingolipid ceramide and its derivative, sphingosine-1-phosphate (S1P), can act synergistically on embryonic stem (ES) cell differentiation. We show here simple methods to analyze sphingolipids in differentiating ES cells and to use ceramide and S1P analogs for the guided differentiation of mouse ES cells toward neuronal and glial lineage.

Original languageEnglish
Title of host publicationSphingosine-1-Phosphate
Subtitle of host publicationMethods and Protocols
EditorsAlice Pebay, Kursad Turksen
Number of pages16
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Apoptosis
  • Ceramide
  • Neuroprogenitor
  • Oligodendrocyte precursor
  • Sphingolipid
  • Sphingosine-1-phosphate
  • Teratoma

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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