Cerebral hemodynamics and cerebral blood volume: MR assessment using gadolinium contrast agents and T1-weighted turbo-FLASH imaging

B. L. Dean, C. Lee, J. E. Kirsch, V. M. Runge, R. M. Dempsey, L. C. Pettigrew

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Purpose: To assess the degree and regional pattern of first-pass brain enhancement using dynamic MR imaging. Materials and Methods: Ultrafast MR imaging (1.06-second acquisition time per image) was performed in 19 healthy subjects following a bolus IV injection of a gadolinium contrast agent; 36 patients with suspected pathology were studied using the same protocol. Results: Calculated percent blood volumes were 4.9% for right cortical gray matter, 4.8% for left cortical gray matter, and 2.6% for white matter. Subtraction images were obtained that depicted the first pass ''blood pool'' pattern of enhancement (gray and white matter) which was significant. Conclusion: Preliminary evidence suggests utility for cerebral ''blood pool'' imaging, especially if reduced image acquisition times can be achieved.

Original languageEnglish
Pages (from-to)39-48
Number of pages10
JournalAmerican Journal of Neuroradiology
Volume13
Issue number1
StatePublished - 1992

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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