Purpose: To assess the degree and regional pattern of first-pass brain enhancement using dynamic MR imaging. Materials and Methods: Ultrafast MR imaging (1.06-second acquisition time per image) was performed in 19 healthy subjects following a bolus IV injection of a gadolinium contrast agent; 36 patients with suspected pathology were studied using the same protocol. Results: Calculated percent blood volumes were 4.9% for right cortical gray matter, 4.8% for left cortical gray matter, and 2.6% for white matter. Subtraction images were obtained that depicted the first pass ''blood pool'' pattern of enhancement (gray and white matter) which was significant. Conclusion: Preliminary evidence suggests utility for cerebral ''blood pool'' imaging, especially if reduced image acquisition times can be achieved.