TY - JOUR
T1 - Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound
AU - Buckley, Erin M.
AU - Cook, Noah M.
AU - Durduran, Turgut
AU - Kim, Meeri N.
AU - Zhou, Chao
AU - Choe, Regine
AU - Yu, Guoqiang
AU - Shultz, Susan
AU - Sehgal, Chandra M.
AU - Licht, Daniel J.
AU - Arger, Peter H.
AU - Putt, Mary E.
AU - Hurt, Hallam
AU - Yodh, Arjun G.
PY - 2009/7/20
Y1 - 2009/7/20
N2 - Four very low birth weight, very premature infants were monitored during a 12° postural elevation using diffuse correlation spectroscopy (DCS) to measure microvascular cerebral blood flow (CBF) and transcranial Doppler ultrasound (TCD) to measure macrovascular blood flow velocity in the middle cerebral artery. DCS data correlated significantly with peak systolic, end diastolic, and mean velocities measured by TCD (pA =0.036, 0.036, 0.047). Moreover, population averaged TCD and DCS data yielded no significant hemodynamic response to this postural change (p≥0.05). We thus demonstrate feasibility of DCS in this population, we show correlation between absolute measures of blood flow from DCS and blood flow velocity from TCD, and we do not detect significant changes in CBF associated with a small postural change (12°) in these patients.
AB - Four very low birth weight, very premature infants were monitored during a 12° postural elevation using diffuse correlation spectroscopy (DCS) to measure microvascular cerebral blood flow (CBF) and transcranial Doppler ultrasound (TCD) to measure macrovascular blood flow velocity in the middle cerebral artery. DCS data correlated significantly with peak systolic, end diastolic, and mean velocities measured by TCD (pA =0.036, 0.036, 0.047). Moreover, population averaged TCD and DCS data yielded no significant hemodynamic response to this postural change (p≥0.05). We thus demonstrate feasibility of DCS in this population, we show correlation between absolute measures of blood flow from DCS and blood flow velocity from TCD, and we do not detect significant changes in CBF associated with a small postural change (12°) in these patients.
UR - http://www.scopus.com/inward/record.url?scp=67749133693&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67749133693&partnerID=8YFLogxK
U2 - 10.1364/OE.17.012571
DO - 10.1364/OE.17.012571
M3 - Article
C2 - 19654660
AN - SCOPUS:67749133693
SN - 1094-4087
VL - 17
SP - 12571
EP - 12581
JO - Optics Express
JF - Optics Express
IS - 15
ER -