Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound

Erin M. Buckley, Noah M. Cook, Turgut Durduran, Meeri N. Kim, Chao Zhou, Regine Choe, Guoqiang Yu, Susan Shultz, Chandra M. Sehgal, Daniel J. Licht, Peter H. Arger, Mary E. Putt, Hallam Hurt, Arjun G. Yodh

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

Four very low birth weight, very premature infants were monitored during a 12° postural elevation using diffuse correlation spectroscopy (DCS) to measure microvascular cerebral blood flow (CBF) and transcranial Doppler ultrasound (TCD) to measure macrovascular blood flow velocity in the middle cerebral artery. DCS data correlated significantly with peak systolic, end diastolic, and mean velocities measured by TCD (pA =0.036, 0.036, 0.047). Moreover, population averaged TCD and DCS data yielded no significant hemodynamic response to this postural change (p≥0.05). We thus demonstrate feasibility of DCS in this population, we show correlation between absolute measures of blood flow from DCS and blood flow velocity from TCD, and we do not detect significant changes in CBF associated with a small postural change (12°) in these patients.

Original languageEnglish
Pages (from-to)12571-12581
Number of pages11
JournalOptics Express
Volume17
Issue number15
DOIs
StatePublished - Jul 20 2009

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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