Cerebrospinal fluid biomarkers in clinical subtypes of early-onset alzheimer's disease

Edmond Teng, Tritia R. Yamasaki, Michelle Tran, Julia J. Hsiao, David L. Sultzer, Mario F. Mendez

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Background/Aims: Accurate diagnosis of sporadic early-onset Alzheimer's disease (EOAD) can be challenging, and cerebrospinal fluid (CSF) biomarkers may assist in this process. We compared CSF indices between three EOAD subtypes: amnestic, logopenic progressive aphasia (LPA), and posterior cortical atrophy (PCA). Methods: We identified 21 amnestic EOAD, 20 LPA, and 12 PCA patients with CSF data, which included amyloid β1-42 (Aβ42), total tau (t-tau), phospho-tau181 (p-tau), and Aβ42/t-tau index (ATI) levels. Results: Aβ42 and ATI levels were similar across groups, but t-tau and p-tau levels were significantly lower in PCA patients. Conclusions: The Aβ42 and ATI data confirm the commonality of the Aβ pathology in EOAD. The lower tau indices in PCA patients may reflect differences in the distribution of neurofibrillary tangles or rates of neurodegeneration.

Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalDementia and Geriatric Cognitive Disorders
Volume37
Issue number5-6
DOIs
StatePublished - Jun 2014

Keywords

  • Amyloid
  • Biological markers
  • Cerebrospinal fluid
  • Early-onset Alzheimer's disease
  • Logopenic progressive aphasia
  • Posterior cortical atrophy
  • Tau

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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