Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

Donna M. Wilcock; Frederick A. Schmitt; Elizabeth Head

doi:10.1016/j.bbadis.2015.11.007

Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

Donna M. Wilcock, Frederick A. Schmitt, Elizabeth Head

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Down syndrome (DS) is a common cause of intellectual disability and is also associated with early age of onset of Alzheimer's disease (AD). Due to an extra copy of chromosome 21, most adults over 40 years old with DS have beta-amyloid plaques as a result of overexpression of the amyloid precursor protein. Cerebrovascular pathology may also be a significant contributor to neuropathology observed in the brains of adults with DS. This review describes the features of cardiovascular dysfunction and cerebrovascular pathology in DS that may be modifiable risk factors and thus targets for interventions. We will describe cerebrovascular pathology, the role of co-morbidities, imaging studies indicating vascular pathology and the possible consequences. It is clear that our understanding of aging and AD in people with DS will benefit from further studies to determine the role that cerebrovascular dysfunction contributes to cognitive health. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

Original language	English
Pages (from-to)	909-914
Number of pages	6
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1862
Issue number	5
DOIs	https://doi.org/10.1016/j.bbadis.2015.11.007
State	Published - May 1 2016

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Funding

Study funding: Supported by Eunice Kennedy Shriver National Institute of Child Health and Development of the National Institutes of Health Grant Number — R01HD064993 and Alzheimer's Association grant DSADNIP-13-282631 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors appreciate the editorial assistance from Ms. Paula Thomason at the University of Kentucky.

Funders	Funder number
National Institutes of Health (NIH)	R01HD064993
National Institutes of Health (NIH)
Alzheimer's Association	DSADNIP-13-282631
Alzheimer's Association
Eunice Kennedy Shriver National Institute of Child Health and Human Development

Keywords

Beta-amyloid
Cerebral amyloid angiopathy
Hypertension
Hypotension
Microhemorrhages
Moyamoya
Sleep apnea
Stroke

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.bbadis.2015.11.007

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title = "Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome",

abstract = "Down syndrome (DS) is a common cause of intellectual disability and is also associated with early age of onset of Alzheimer's disease (AD). Due to an extra copy of chromosome 21, most adults over 40 years old with DS have beta-amyloid plaques as a result of overexpression of the amyloid precursor protein. Cerebrovascular pathology may also be a significant contributor to neuropathology observed in the brains of adults with DS. This review describes the features of cardiovascular dysfunction and cerebrovascular pathology in DS that may be modifiable risk factors and thus targets for interventions. We will describe cerebrovascular pathology, the role of co-morbidities, imaging studies indicating vascular pathology and the possible consequences. It is clear that our understanding of aging and AD in people with DS will benefit from further studies to determine the role that cerebrovascular dysfunction contributes to cognitive health. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.",

keywords = "Beta-amyloid, Cerebral amyloid angiopathy, Hypertension, Hypotension, Microhemorrhages, Moyamoya, Sleep apnea, Stroke",

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doi = "10.1016/j.bbadis.2015.11.007",

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AU - Schmitt, Frederick A.

AU - Head, Elizabeth

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N2 - Down syndrome (DS) is a common cause of intellectual disability and is also associated with early age of onset of Alzheimer's disease (AD). Due to an extra copy of chromosome 21, most adults over 40 years old with DS have beta-amyloid plaques as a result of overexpression of the amyloid precursor protein. Cerebrovascular pathology may also be a significant contributor to neuropathology observed in the brains of adults with DS. This review describes the features of cardiovascular dysfunction and cerebrovascular pathology in DS that may be modifiable risk factors and thus targets for interventions. We will describe cerebrovascular pathology, the role of co-morbidities, imaging studies indicating vascular pathology and the possible consequences. It is clear that our understanding of aging and AD in people with DS will benefit from further studies to determine the role that cerebrovascular dysfunction contributes to cognitive health. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

AB - Down syndrome (DS) is a common cause of intellectual disability and is also associated with early age of onset of Alzheimer's disease (AD). Due to an extra copy of chromosome 21, most adults over 40 years old with DS have beta-amyloid plaques as a result of overexpression of the amyloid precursor protein. Cerebrovascular pathology may also be a significant contributor to neuropathology observed in the brains of adults with DS. This review describes the features of cardiovascular dysfunction and cerebrovascular pathology in DS that may be modifiable risk factors and thus targets for interventions. We will describe cerebrovascular pathology, the role of co-morbidities, imaging studies indicating vascular pathology and the possible consequences. It is clear that our understanding of aging and AD in people with DS will benefit from further studies to determine the role that cerebrovascular dysfunction contributes to cognitive health. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

KW - Beta-amyloid

KW - Cerebral amyloid angiopathy

KW - Hypertension

KW - Hypotension

KW - Microhemorrhages

KW - Moyamoya

KW - Sleep apnea

KW - Stroke

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Cerebrovascular contributions to aging and Alzheimer's disease in Down syndrome

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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