TY - JOUR
T1 - Changes in central venous pressure and blood lactate concentration in response to acute blood loss in horses
AU - Magdesian, K. Gary
AU - Fielding, C. Langdon
AU - Rhodes, Diane M.
AU - Ruby, Rebecca E.
PY - 2006/11/1
Y1 - 2006/11/1
N2 - Objective - To evaluate selected hemodynamic, blood gas, and biochemical responses to mild to moderate acute blood loss in standing, awake horses. Design - Prospective study. Animals - 7 healthy mares. Procedures - Each horse was restrained in standing stocks, and its head was maintained in a neutral position; sedatives and tranquilizers were not administered. During a 1-hour period, blood was collected into collection bags by use of a suction pump. The rate of blood collection was approximately 16 mL/kg/h (7.3 mL/lb/h). Thirty minutes after blood collection, the blood was readministered at the same rate. Central venous pressure (CVP), central venous blood gas, blood lactate concentration, and heart rate were measured at baseline (after placement of catheters), after removal of blood, and after readministration of blood. Results - In response to blood loss, CVP decreased and blood lactate concentration increased significantly, compared with baseline values; heart rate and results of central venous blood gas analysis did not change significantly. After readministration of blood, CVP returned to baseline value and blood lactate concentration approached baseline value. Conclusions and Clinical Relevance - Changes in CVP and blood lactate concentration appear to be early indicators of hypovolemia in horses, which may represent acute blood loss in trauma patients; these variables should be monitored to assess the potential need for blood transfusions. These variables can be used to monitor responses of horses to blood transfusions when whole blood is administered as the replacement fluid.
AB - Objective - To evaluate selected hemodynamic, blood gas, and biochemical responses to mild to moderate acute blood loss in standing, awake horses. Design - Prospective study. Animals - 7 healthy mares. Procedures - Each horse was restrained in standing stocks, and its head was maintained in a neutral position; sedatives and tranquilizers were not administered. During a 1-hour period, blood was collected into collection bags by use of a suction pump. The rate of blood collection was approximately 16 mL/kg/h (7.3 mL/lb/h). Thirty minutes after blood collection, the blood was readministered at the same rate. Central venous pressure (CVP), central venous blood gas, blood lactate concentration, and heart rate were measured at baseline (after placement of catheters), after removal of blood, and after readministration of blood. Results - In response to blood loss, CVP decreased and blood lactate concentration increased significantly, compared with baseline values; heart rate and results of central venous blood gas analysis did not change significantly. After readministration of blood, CVP returned to baseline value and blood lactate concentration approached baseline value. Conclusions and Clinical Relevance - Changes in CVP and blood lactate concentration appear to be early indicators of hypovolemia in horses, which may represent acute blood loss in trauma patients; these variables should be monitored to assess the potential need for blood transfusions. These variables can be used to monitor responses of horses to blood transfusions when whole blood is administered as the replacement fluid.
UR - http://www.scopus.com/inward/record.url?scp=33750574933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750574933&partnerID=8YFLogxK
U2 - 10.2460/javma.229.9.1458
DO - 10.2460/javma.229.9.1458
M3 - Article
C2 - 17078809
AN - SCOPUS:33750574933
SN - 0003-1488
VL - 229
SP - 1458
EP - 1462
JO - Journal of the American Veterinary Medical Association
JF - Journal of the American Veterinary Medical Association
IS - 9
ER -