Changes in dopamine and DOPAC following systemic administration of apomorphine and 3,4-dihydroxyphenylamino-2-imidazoline (DPI) in rats

Joe Springer, John H. Hannigan, Robert L. Isaacson

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Rats were injected systemically with either saline, apomorphine, or one of four doses of DPI (3,4-dihydroxyphenylamino-2-imidazoline) and the levels of dopamine and DOPAC determined in the nucleus accumbens and the caudate regions. DPI reduced dopamine and DOPAC levels in the nucleus accumbens, while apomorphine did not. On the other hand, apomorphine reduced the levels of dopamine and DOPAC in the caudate but not the nucleus accumbens. DPI largely was without effect in the caudate. The results are discussed in terms of possible specificity of the two dopamine agonists in the two forebrain regions.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalBrain Research
Volume220
Issue number1
DOIs
StatePublished - Sep 7 1981

Keywords

  • 3,4-dihydroxyphenylamino-2-imidazoline
  • caudate
  • dopamine receptors
  • nucleus accumbens

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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