Changes in gene expression

Peng Jiang, Bruce F. O'Hara

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Loss of sleep is associated with profound changes in gene expression, studies of which have led to important implications regarding sleep functions and homeostatic regulation. In this article, we summarize findings from gene expression studies of sleep-deprived animals. We highlight five categories of genes that are consistently found to be differentially expressed across different studies, including activity-dependent immediate-early genes, genes involved in synaptic plasticity, metabolic genes, genes involved in inflammation, and circadian clock genes. We also provide a brief discussion of how expression changes in these genes are consistent with some of the leading hypotheses regarding the functions and homeostatic regulation of sleep.

Original languageEnglish
Title of host publicationEncyclopedia of Sleep and Circadian Rhythms
Subtitle of host publicationVolume 1-6, Second Edition
Number of pages6
ISBN (Electronic)9780323910941
StatePublished - Jan 1 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc. All rights reserved


  • Gene expression
  • Homeostasis
  • Microarray
  • RNA-seq
  • Rodents
  • Sleep
  • Sleep deprivation
  • Transcriptomics

ASJC Scopus subject areas

  • General Neuroscience


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