Anthropomorphic software breast phantoms are generated by simulating breast anatomy. Virtual Clinical Trial (VCT) tools are developed for evaluating novel imaging modalities, based on anthropomorphic breast phantoms. Simulation of breast anatomical structures requires informed selection of parameters, which is crucial for the simulation realism. Our goal is to optimize the parameter selection based upon the analysis of clinical images. Adipose compartments defined by Cooper's ligaments significantly contribute to breast image texture (parenchymal pattern) which affects image interpretation and lesion detection. We have investigated the distribution and orientation of compartments segmented from CT images of a mastectomy specimen. Ellipsoidal fitting was applied to 205 segmented compartments, by matching the moments of inertia. The goodness-of-fit was measured by calculating Dice coefficients. Compartment size, shape, and orientation were characterized by estimating the volume, axis ratio, and Euler's angles of fitted ellipsoids. Potential correlations between estimated parameters were tested. We found that the adipose compartments are well approximated with ellipsoids (average Dice coefficient of 0.79). The compartment size is correlated with the barycenter-chest wall distance (r=0.235, p-value<0.001). The goodness-of-fit to ellipsoids is correlated to the compartment shape (r=0.344, p-value<0.001). The shape is also correlated with barycenter coordinates. The compartment orientation is correlated to their size (Euler angle α: r=0.188, p-value=0.007; angle β: r=0.156, p-value=0.025) and the barycenter-chest wall distance (r=0.159, p-value=0.023). These results from the characterization of adipose compartments and the observed correlations could help improve the realism of simulated breast anatomy.
|Title of host publication||Medical Imaging 2018|
|Subtitle of host publication||Physics of Medical Imaging|
|Editors||Taly Gilat Schmidt, Guang-Hong Chen, Joseph Y. Lo|
|State||Published - 2018|
|Event||Medical Imaging 2018: Physics of Medical Imaging - Houston, United States|
Duration: Feb 12 2018 → Feb 15 2018
|Name||Progress in Biomedical Optics and Imaging - Proceedings of SPIE|
|Conference||Medical Imaging 2018: Physics of Medical Imaging|
|Period||2/12/18 → 2/15/18|
Bibliographical noteFunding Information:
This research was supported by a grant from the National Institute of General Medical Sciences (P20 GM103446) from the National Institutes of Health. Also, the work was supported in part by the US Department of Defense Breast Cancer Research Program (HBCU Partnership Training Award #BC083639), the US National Science Foundation (CREST grant #HRD-1242067), the US Department of Defense/Department of Army (Award #W911NF-11-2-0046), the US National Institutes of Health (R01 grant #CA154444), and the Komen Foundation (grant #IIR13262248). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, DoD, and Komen Foundation. The first author performed the presented work as a graduate student at Delaware State University.
© 2018 SPIE.
- adipose compartments
- Anthropomorphic breast phantom
- breast cancer imaging
- ellipsoidal fitting
- mastectomy specimen images
- Virtual Clinical Trials
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging