Abstract
Anthropomorphic software breast phantoms are generated by simulating breast anatomy. Virtual Clinical Trial (VCT) tools are developed for evaluating novel imaging modalities, based on anthropomorphic breast phantoms. Simulation of breast anatomical structures requires informed selection of parameters, which is crucial for the simulation realism. Our goal is to optimize the parameter selection based upon the analysis of clinical images. Adipose compartments defined by Cooper's ligaments significantly contribute to breast image texture (parenchymal pattern) which affects image interpretation and lesion detection. We have investigated the distribution and orientation of compartments segmented from CT images of a mastectomy specimen. Ellipsoidal fitting was applied to 205 segmented compartments, by matching the moments of inertia. The goodness-of-fit was measured by calculating Dice coefficients. Compartment size, shape, and orientation were characterized by estimating the volume, axis ratio, and Euler's angles of fitted ellipsoids. Potential correlations between estimated parameters were tested. We found that the adipose compartments are well approximated with ellipsoids (average Dice coefficient of 0.79). The compartment size is correlated with the barycenter-chest wall distance (r=0.235, p-value<0.001). The goodness-of-fit to ellipsoids is correlated to the compartment shape (r=0.344, p-value<0.001). The shape is also correlated with barycenter coordinates. The compartment orientation is correlated to their size (Euler angle α: r=0.188, p-value=0.007; angle β: r=0.156, p-value=0.025) and the barycenter-chest wall distance (r=0.159, p-value=0.023). These results from the characterization of adipose compartments and the observed correlations could help improve the realism of simulated breast anatomy.
Original language | English |
---|---|
Title of host publication | Medical Imaging 2018 |
Subtitle of host publication | Physics of Medical Imaging |
Editors | Taly Gilat Schmidt, Guang-Hong Chen, Joseph Y. Lo |
ISBN (Electronic) | 9781510616356 |
DOIs | |
State | Published - 2018 |
Event | Medical Imaging 2018: Physics of Medical Imaging - Houston, United States Duration: Feb 12 2018 → Feb 15 2018 |
Publication series
Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
---|---|
Volume | 10573 |
ISSN (Print) | 1605-7422 |
Conference
Conference | Medical Imaging 2018: Physics of Medical Imaging |
---|---|
Country/Territory | United States |
City | Houston |
Period | 2/12/18 → 2/15/18 |
Bibliographical note
Publisher Copyright:© 2018 SPIE.
Keywords
- Anthropomorphic breast phantom
- Virtual Clinical Trials
- adipose compartments
- breast cancer imaging
- ellipsoidal fitting
- mastectomy specimen images
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging
- Biomaterials