Characterization of ovine nectin-4, a novel peste des petits ruminants virus receptor

Jamie Birch, Nicholas Juleff, Michael P. Heaton, Ted Kalbfleisch, James Kijas, Dalan Bailey

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Small ruminants infected with peste des petits ruminants virus exhibit lesions typical of epithelial infection and necrosis. However, the only established host receptor for this virus is the immune cell marker signaling lymphocyte activation molecule (SLAM). We have confirmed that the ovine Nectin-4 protein, when overexpressed in epithelial cells, permits efficient replication of PPRV. Furthermore, this gene was predominantly expressed in epithelial tissues and encoded by multiple haplotypes in sheep breeds from around the world.

Original languageEnglish
Pages (from-to)4756-4761
Number of pages6
JournalJournal of Virology
Volume87
Issue number8
DOIs
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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