Characterization of seven DA/DAPI-positive bisatellited marker chromosomes by in situ hybridization

Rina Plattner, Nyla A. Heerema, Shivanand R. Patil, Patricia N. Howard-Peebles, Catherine G. Palmer

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Seven dicentric bisatellited marker chromosomes, ascertained at amniocentesis, chorionic villus sampling, and in blood from an abnormal liveborn were characterized cytogenetically. All seven markers demonstrated brilliant bands by the DA/DAPI technique corresponding to C-band positive regions. Although some dicentric DA/DAPI-positive bisatellited markers have been identified as inverted duplicated 15s, recent literature has suggested that DA/DAPI lacks specificity for chromosome 15. Our evaluation of DA/DAPI-positive bisatellited marker chromosomes by in situ hybridization shows that some originate from chromosome 15 whereas DA/DAPI negative bisatellited markers may not be derived from 15. The morphological variations noted in our studies are discussed with respect to nomenclature.

Original languageEnglish
Pages (from-to)290-296
Number of pages7
JournalHuman Genetics
Volume87
Issue number3
DOIs
StatePublished - Jul 1991

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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