@article{d93e4d56569e4b7ea2ebd086bb610ef4,
title = "Characterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6",
abstract = "Although bacterial iterative type I polyketide synthases are now known to participate in the biosynthesis of a small set of diverse natural products, the subsequent downstream modification of the resulting polyketide products is poorly understood. We report the functional characterization of the putative orsellinic acid C2-O-methyltransferase, which is involved in calicheamicin biosynthesis. This study suggests that C2-O-methylation precedes C3-hydroxylation/methylation and C5-iodination and requires a coenzyme A- or acyl carrier protein-bound substrate.",
keywords = "AdoMet, S-adenosylmethionine, acyl carrier proteins, iterative PKSs, orsellinic acid, polyketides",
author = "Shanteri Singh and Nandurkar, \{Nitin S.\} and Thorson, \{Jon S.\}",
year = "2014",
month = jul,
day = "7",
doi = "10.1002/cbic.201402119",
language = "English",
volume = "15",
pages = "1418--1421",
number = "10",
}