Characterization of the conditioned taste aversion produced by 7-OH-DPAT in rats

Rick A. Bevins, Timothy A. Delzer, Michael T. Bardo

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Using the conditioned taste aversion preparation, we described the dose-effect curve for the reputed dopamine D3 agonist (±)7-OH-DPAT (0, 0.001, 0.01, 0.1, 1.0, or 10 mg/kg). Rats received a 0.1% saccharin taste paired on repeated occasions with one of the 7-OH-DPAT doses. The 0.1, 1.0, and 10.0 mg/kg doses of 7-OH-DPAT produced a significant conditioned saccharin aversion. This aversion was evident regardless of whether saccharin intake of 7-OH-DPAT-treated rats was compared to their own water consumption or to saccharin intake by saline-treated rats.

Original languageEnglish
Pages (from-to)695-699
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume53
Issue number3
DOIs
StatePublished - Mar 1996

Bibliographical note

Funding Information:
This work was funded by United States Public Health Service Grant DA05623 to R. A. Bevins and Grants DA05312 and DA07746 to M. T. Bardo. We thank Patricia Robinet and Joanne Valone for comments on an earlier version of this manuscript.

Keywords

  • 7-Hydroxy-N,N-di-n-propyl-2-aminotetralin
  • 7-OH-DPAT
  • Amphetamine
  • Cocaine
  • D receptor
  • D receptor
  • Dopamine
  • Reward
  • Saccharin taste aversion
  • Sigma receptor

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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