Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family)

Jannifer Oliveira Chiang; William Marciel de Souza; Márcio Roberto Teixeira Nunes; Gustavo Olszanski Acrani; Amélia Paes de Andrade Travassos da Rosa; Nelma Mesquita de Freitas; Sandro Patroca da Silva; Pedro Henrique Dorta da Silva; Alana Watanabe de Sousa; Sueli Guerreiro Rodrigues; Juarez Antônio Simões Quaresma; Bedsy Dutary; Hilda Guzmán; Nikos Vasilakis; Robert B. Tesh; Pedro Fernando da Costa Vasconcelos

doi:10.4269/ajtmh.17-0810

Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family)

Jannifer Oliveira Chiang
, William Marciel de Souza
, Márcio Roberto Teixeira Nunes
, Gustavo Olszanski Acrani
, Amélia Paes de Andrade Travassos da Rosa
, Nelma Mesquita de Freitas
, Sandro Patroca da Silva
, Pedro Henrique Dorta da Silva
, Alana Watanabe de Sousa
, Sueli Guerreiro Rodrigues
, Juarez Antônio Simões Quaresma
, Bedsy Dutary
, Hilda Guzmán
, Nikos Vasilakis
, Robert B. Tesh
, Pedro Fernando da Costa Vasconcelos

Microbiology, Immunology, and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Comprehensive comparative phylogenetic analyses were performed on 17 Gamboa serogroup viruses (GAMSVs) from distinct geographic regions in the Americas and other representative members of the genus Orthobunyavirus (Peribunyaviridae), based on small (S), medium (M), and large (L) open reading frame full-length and partial sequences. Genome characterization showed that the GAMSVs divide into four clades or genotypes. The GAMSVs have a genetic organization similar to other orthobunyaviruses, except that they have a larger NSm protein than other orthobunyaviruses. A serosurvey for Gamboa virus antibodies was performed in plasma from birds, other wild animals, and humans living around the Tucuruí hydroelectric dam in Pará state, northern Brazil, a known focus of GAMSV activity. Newborn chicks (Gallus gallus domesticus) were experimentally infected with a GAMSV, and the pathogenesis is described. Histopathological changes were primarily in the lungs and liver. Also, a review of the ecology of the GAMSVs in the Americas is included. In sum, this study presents the genomic and evolutionary characterization of the Gamboa group and the potential model of pathogenesis, which would be helpful for diagnostic purposes, epidemiology, and immuno-pathogenesis studies.

Original language	English
Pages (from-to)	1502-1511
Number of pages	10
Journal	American Journal of Tropical Medicine and Hygiene
Volume	98
Issue number	5
DOIs	https://doi.org/10.4269/ajtmh.17-0810
State	Published - 2018

Bibliographical note

Publisher Copyright:
Copyright © 2018 by The American Society of Tropical Medicine and Hygiene.

Funding

Financial support: Work in Brazil was partially supported by CNPq grants 302987/2008-8, 302584/2015-3 (MRTN), 303999/2016-0, and 457664/2013-4 (PICV), CAPES (JOC), and the Instituto Evandro Chagas/Brazilian Ministry of Health. W.M.d.S. was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (Scholarships No. 12/24150-9 and 15/05778-5). Work in Panama was supported in part by grants AI02984, AI11889, and AI22122 from the U.S. National Institutes of Health (NIH). Work in the United States was supported by NIH grant 1R24 AI120942 and contract HHSN272201000040I/HHSN27200004/D04. We thank the staff of the Department of Arbovirology and Hemorrhagic Fevers of Evandro Chagas Institute and Department of Pathology of the University of Texas Medical Branch for their technical support. Nucleotide sequence accession number: The nucleotide sequences determined in this study have been deposited in GenBank under the accession number FX900423 to FX900443, and MG019911 to MG019913. Work in Brazil was partially supported by CNPq grants 302987/2008-8, 302584/2015-3 (MRTN), 303999/2016-0, and 457664/2013-4 (PICV), CAPES (JOC), and the Instituto Evandro Chagas/Brazilian Ministry of Health. W.M.d.S. was supported by the Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo, Brazil (Scholarships No. 12/24150-9 and 15/05778-5). Work in Panama was supported in part by grants AI02984, AI11889, and AI22122 from the U.S. National Institutes of Health (NIH). Work in the United States was supported by NIH grant 1R24 AI120942 and contract HHSN272201000040I/HHSN27200004/D04. We thank the staff of the Department of Arbovirology and Hemorrhagic Fevers of Evandro Chagas Institute and Department of Pathology of the University of Texas Medical Branch for their technical support. Nucleotide sequence accession number: The nucleotide sequences determined in this study have been deposited in GenBank under the accession number FX900423 to FX900443, and MG019911 to MG019913. Work in Brazil was partially supported by CNPq grants 302987/2008-8, 302584/2015-3 (MRTN), 303999/2016-0, and 457664/2013-4 (PICV), CAPES (JOC), and the Instituto Evandro Chagas/Brazilian Ministry of Health. W.M.d.S. was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (Scholarships No. 12/24150-9 and 15/05778-5). Work in Panama was supported in part by grants AI02984, AI11889, and AI22122 from the U.S. National Institutes of Health (NIH). Work in the United States was supported by NIH grant 1R24 AI120942 and contract HHSN272201000040I/HHSN27200004/D04.

Funders	Funder number
Instituto Evandro Chagas
Instituto Evandro Chagas/Brazilian Ministry of Health
JOC
PICV
National Institutes of Health (NIH)	HHSN272201000040I/HHSN27200004/D04, 1R24 AI120942, HHSN27200004/D04
Foundation for the National Institutes of Health
W. M. Keck Foundation
University of Texas Medical Branch	MG019911, MG019913, FX900443, FX900423
Fundação de Amparo à Pesquisa do Estado de São Paulo	AI11889, AI22122, AI02984, 12/24150-9, 15/05778-5
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico	302987/2008-8, 303999/2016-0, 302584/2015-3, 457664/2013-4
Ministério da Saúde
Instituto Euvaldo Lodi

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

Access to Document

10.4269/ajtmh.17-0810

Cite this

Chiang, J. O., de Souza, W. M., Nunes, M. R. T., Acrani, G. O., Travassos da Rosa, A. P. D. A., de Freitas, N. M., da Silva, S. P., da Silva, P. H. D., de Sousa, A. W., Rodrigues, S. G., Quaresma, J. A. S., Dutary, B., Guzmán, H., Vasilakis, N., Tesh, R. B., & Vasconcelos, P. F. D. C. (2018). Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family). American Journal of Tropical Medicine and Hygiene, 98(5), 1502-1511. https://doi.org/10.4269/ajtmh.17-0810

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title = "Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family)",

abstract = "Comprehensive comparative phylogenetic analyses were performed on 17 Gamboa serogroup viruses (GAMSVs) from distinct geographic regions in the Americas and other representative members of the genus Orthobunyavirus (Peribunyaviridae), based on small (S), medium (M), and large (L) open reading frame full-length and partial sequences. Genome characterization showed that the GAMSVs divide into four clades or genotypes. The GAMSVs have a genetic organization similar to other orthobunyaviruses, except that they have a larger NSm protein than other orthobunyaviruses. A serosurvey for Gamboa virus antibodies was performed in plasma from birds, other wild animals, and humans living around the Tucuru{\'i} hydroelectric dam in Par{\'a} state, northern Brazil, a known focus of GAMSV activity. Newborn chicks (Gallus gallus domesticus) were experimentally infected with a GAMSV, and the pathogenesis is described. Histopathological changes were primarily in the lungs and liver. Also, a review of the ecology of the GAMSVs in the Americas is included. In sum, this study presents the genomic and evolutionary characterization of the Gamboa group and the potential model of pathogenesis, which would be helpful for diagnostic purposes, epidemiology, and immuno-pathogenesis studies.",

author = "Chiang, \{Jannifer Oliveira\} and \{de Souza\}, \{William Marciel\} and Nunes, \{M{\'a}rcio Roberto Teixeira\} and Acrani, \{Gustavo Olszanski\} and \{Travassos da Rosa\}, \{Am{\'e}lia Paes de Andrade\} and \{de Freitas\}, \{Nelma Mesquita\} and \{da Silva\}, \{Sandro Patroca\} and \{da Silva\}, \{Pedro Henrique Dorta\} and \{de Sousa\}, \{Alana Watanabe\} and Rodrigues, \{Sueli Guerreiro\} and Quaresma, \{Juarez Ant{\^o}nio Sim{\~o}es\} and Bedsy Dutary and Hilda Guzm{\'a}n and Nikos Vasilakis and Tesh, \{Robert B.\} and Vasconcelos, \{Pedro Fernando da Costa\}",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 by The American Society of Tropical Medicine and Hygiene.",

year = "2018",

doi = "10.4269/ajtmh.17-0810",

language = "English",

volume = "98",

pages = "1502--1511",

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Chiang, JO, de Souza, WM, Nunes, MRT, Acrani, GO, Travassos da Rosa, APDA, de Freitas, NM, da Silva, SP, da Silva, PHD, de Sousa, AW, Rodrigues, SG, Quaresma, JAS, Dutary, B, Guzmán, H, Vasilakis, N, Tesh, RB & Vasconcelos, PFDC 2018, 'Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family)', American Journal of Tropical Medicine and Hygiene, vol. 98, no. 5, pp. 1502-1511. https://doi.org/10.4269/ajtmh.17-0810

TY - JOUR

T1 - Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family)

AU - Chiang, Jannifer Oliveira

AU - de Souza, William Marciel

AU - Nunes, Márcio Roberto Teixeira

AU - Acrani, Gustavo Olszanski

AU - Travassos da Rosa, Amélia Paes de Andrade

AU - de Freitas, Nelma Mesquita

AU - da Silva, Sandro Patroca

AU - da Silva, Pedro Henrique Dorta

AU - de Sousa, Alana Watanabe

AU - Rodrigues, Sueli Guerreiro

AU - Quaresma, Juarez Antônio Simões

AU - Dutary, Bedsy

AU - Guzmán, Hilda

AU - Vasilakis, Nikos

AU - Tesh, Robert B.

AU - Vasconcelos, Pedro Fernando da Costa

PY - 2018

Y1 - 2018

N2 - Comprehensive comparative phylogenetic analyses were performed on 17 Gamboa serogroup viruses (GAMSVs) from distinct geographic regions in the Americas and other representative members of the genus Orthobunyavirus (Peribunyaviridae), based on small (S), medium (M), and large (L) open reading frame full-length and partial sequences. Genome characterization showed that the GAMSVs divide into four clades or genotypes. The GAMSVs have a genetic organization similar to other orthobunyaviruses, except that they have a larger NSm protein than other orthobunyaviruses. A serosurvey for Gamboa virus antibodies was performed in plasma from birds, other wild animals, and humans living around the Tucuruí hydroelectric dam in Pará state, northern Brazil, a known focus of GAMSV activity. Newborn chicks (Gallus gallus domesticus) were experimentally infected with a GAMSV, and the pathogenesis is described. Histopathological changes were primarily in the lungs and liver. Also, a review of the ecology of the GAMSVs in the Americas is included. In sum, this study presents the genomic and evolutionary characterization of the Gamboa group and the potential model of pathogenesis, which would be helpful for diagnostic purposes, epidemiology, and immuno-pathogenesis studies.

AB - Comprehensive comparative phylogenetic analyses were performed on 17 Gamboa serogroup viruses (GAMSVs) from distinct geographic regions in the Americas and other representative members of the genus Orthobunyavirus (Peribunyaviridae), based on small (S), medium (M), and large (L) open reading frame full-length and partial sequences. Genome characterization showed that the GAMSVs divide into four clades or genotypes. The GAMSVs have a genetic organization similar to other orthobunyaviruses, except that they have a larger NSm protein than other orthobunyaviruses. A serosurvey for Gamboa virus antibodies was performed in plasma from birds, other wild animals, and humans living around the Tucuruí hydroelectric dam in Pará state, northern Brazil, a known focus of GAMSV activity. Newborn chicks (Gallus gallus domesticus) were experimentally infected with a GAMSV, and the pathogenesis is described. Histopathological changes were primarily in the lungs and liver. Also, a review of the ecology of the GAMSVs in the Americas is included. In sum, this study presents the genomic and evolutionary characterization of the Gamboa group and the potential model of pathogenesis, which would be helpful for diagnostic purposes, epidemiology, and immuno-pathogenesis studies.

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EP - 1511

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 5

ER -

Characterization of the gamboa virus serogroup (orthobunyavirus genus, peribunyaviridae family)

Abstract

Bibliographical note

Funding

UN SDGs

ASJC Scopus subject areas

Access to Document

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