Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C

David A. Litvak; Hideaki Iseki; B. Mark Evers; George H. Greeley; Mark R. Hellmich; Kazuhiro Iwase; Ambikaipakan Balasubramaniam; Courtney M. Townsend

doi:10.1023/A:1026686214004

Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C

David A. Litvak, Hideaki Iseki, B. Mark Evers, George H. Greeley, Mark R. Hellmich, Kazuhiro Iwase, Ambikaipakan Balasubramaniam, Courtney M. Townsend

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.

Original language	English
Pages (from-to)	643-648
Number of pages	6
Journal	Digestive Diseases and Sciences
Volume	44
Issue number	3
DOIs	https://doi.org/10.1023/A:1026686214004
State	Published - 1999

Bibliographical note

Funding Information:
Manuscript receive d June 4, 1998; accepte d October 8, 1998. From the De partme nt of Surgery, The Unive rsity of Texas Medical Branch, Galve ston, Texa; asdntheUnive rsity of Cincinnati Medical Center, Cincinnati, Ohio. Daid vA. Litvak was a visiting scientist from the Universtiy California, Dais-Evast Bay Oakland, California. Presente d, in part, at the Association for Academic Surgery meeting(November6± 8,1997)inDallas,Texas. This work was funded by grants from the National Institutes of Health (PO1 DK36085, T32-DK07633, and GM47122) , and a grant from Biomeasure Inc. (Medford, Massachusetts). Address for reprint requests: Dr. Courtney M. Townsend, Jr., De partme nt of Surgery, The Unive rsity of TexaMsdical Beranch, 301 Unive rsity Boulevard, Galveston, Texa77s5550527-.

Keywords

Intestinal absorption
PYY analog
Peptide YY
Proabsorptive agent

ASJC Scopus subject areas

Physiology
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/A:1026686214004

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title = "Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C",

abstract = "Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.",

keywords = "Intestinal absorption, PYY analog, Peptide YY, Proabsorptive agent",

author = "Litvak, {David A.} and Hideaki Iseki and Evers, {B. Mark} and Greeley, {George H.} and Hellmich, {Mark R.} and Kazuhiro Iwase and Ambikaipakan Balasubramaniam and Townsend, {Courtney M.}",

note = "Funding Information: Manuscript receive d June 4, 1998; accepte d October 8, 1998. From the De partme nt of Surgery, The Unive rsity of Texas Medical Branch, Galve ston, Texa; asdntheUnive rsity of Cincinnati Medical Center, Cincinnati, Ohio. Daid vA. Litvak was a visiting scientist from the Universtiy California, Dais-Evast Bay Oakland, California. Presente d, in part, at the Association for Academic Surgery meeting(November6± 8,1997)inDallas,Texas. This work was funded by grants from the National Institutes of Health (PO1 DK36085, T32-DK07633, and GM47122) , and a grant from Biomeasure Inc. (Medford, Massachusetts). Address for reprint requests: Dr. Courtney M. Townsend, Jr., De partme nt of Surgery, The Unive rsity of TexaMsdical Beranch, 301 Unive rsity Boulevard, Galveston, Texa77s5550527-.",

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doi = "10.1023/A:1026686214004",

language = "English",

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AU - Litvak, David A.

AU - Iseki, Hideaki

AU - Evers, B. Mark

AU - Greeley, George H.

AU - Hellmich, Mark R.

AU - Iwase, Kazuhiro

AU - Balasubramaniam, Ambikaipakan

AU - Townsend, Courtney M.

N1 - Funding Information: Manuscript receive d June 4, 1998; accepte d October 8, 1998. From the De partme nt of Surgery, The Unive rsity of Texas Medical Branch, Galve ston, Texa; asdntheUnive rsity of Cincinnati Medical Center, Cincinnati, Ohio. Daid vA. Litvak was a visiting scientist from the Universtiy California, Dais-Evast Bay Oakland, California. Presente d, in part, at the Association for Academic Surgery meeting(November6± 8,1997)inDallas,Texas. This work was funded by grants from the National Institutes of Health (PO1 DK36085, T32-DK07633, and GM47122) , and a grant from Biomeasure Inc. (Medford, Massachusetts). Address for reprint requests: Dr. Courtney M. Townsend, Jr., De partme nt of Surgery, The Unive rsity of TexaMsdical Beranch, 301 Unive rsity Boulevard, Galveston, Texa77s5550527-.

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Y1 - 1999

N2 - Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.

AB - Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM- 43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.

KW - Intestinal absorption

KW - PYY analog

KW - Peptide YY

KW - Proabsorptive agent

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Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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