Chemical methods for the synthesis and modification of neoclerodane diterpenes

Anthony Lozama, Thomas E. Prisinzano

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.

Original languageEnglish
Pages (from-to)5490-5495
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number18
StatePublished - Sep 15 2009

Bibliographical note

Funding Information:
The authors would like to thank the National Institute of Health and the National Institute on Drug Abuse, as well as the Universities of Iowa and Kansas for financial support of our ongoing research efforts. A.L. is currently supported by NIDA grant DA018151S1.


  • Diterpene
  • Neoclerodane
  • Salvia divinorum
  • Salvinorin A

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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