Chemical methods for the synthesis and modification of neoclerodane diterpenes

Anthony Lozama; Thomas E. Prisinzano

doi:10.1016/j.bmcl.2009.07.069

Chemical methods for the synthesis and modification of neoclerodane diterpenes

Anthony Lozama
, Thomas E. Prisinzano

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.

Original language	English
Pages (from-to)	5490-5495
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2009.07.069
State	Published - Sep 15 2009

Bibliographical note

Funding Information:
The authors would like to thank the National Institute of Health and the National Institute on Drug Abuse, as well as the Universities of Iowa and Kansas for financial support of our ongoing research efforts. A.L. is currently supported by NIDA grant DA018151S1.

Funding

The authors would like to thank the National Institute of Health and the National Institute on Drug Abuse, as well as the Universities of Iowa and Kansas for financial support of our ongoing research efforts. A.L. is currently supported by NIDA grant DA018151S1.

Funders	Funder number
National Institutes of Health/National Institute of Environmental Health Sciences
Universities of Iowa and Kansas
National Institute on Drug Abuse	R01DA018151
National Institute of Development Administration	DA018151S1

Keywords

Diterpene
Neoclerodane
Salvia divinorum
Salvinorin A

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.07.069

Cite this

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title = "Chemical methods for the synthesis and modification of neoclerodane diterpenes",

abstract = "Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.",

keywords = "Diterpene, Neoclerodane, Salvia divinorum, Salvinorin A",

author = "Anthony Lozama and Prisinzano, \{Thomas E.\}",

note = "Funding Information: The authors would like to thank the National Institute of Health and the National Institute on Drug Abuse, as well as the Universities of Iowa and Kansas for financial support of our ongoing research efforts. A.L. is currently supported by NIDA grant DA018151S1. ",

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AU - Prisinzano, Thomas E.

N1 - Funding Information: The authors would like to thank the National Institute of Health and the National Institute on Drug Abuse, as well as the Universities of Iowa and Kansas for financial support of our ongoing research efforts. A.L. is currently supported by NIDA grant DA018151S1.

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N2 - Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.

AB - Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12.

KW - Diterpene

KW - Neoclerodane

KW - Salvia divinorum

KW - Salvinorin A

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VL - 19

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JO - Bioorganic and Medicinal Chemistry Letters

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IS - 18

ER -

Chemical methods for the synthesis and modification of neoclerodane diterpenes

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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