TY - JOUR
T1 - Chemically Triggered Synthesis, Remodeling, and Degradation of Soft Materials
AU - Sun, Xiaolong
AU - Chwatko, Malgorzata
AU - Lee, Doo Hee
AU - Bachman, James L.
AU - Reuther, James F.
AU - Lynd, Nathaniel A.
AU - Anslyn, Eric V.
N1 - Publisher Copyright:
© 2020 American Chemical Society.
PY - 2020/2/26
Y1 - 2020/2/26
N2 - Polymer topology dictates dynamic and mechanical properties of materials. For most polymers, topology is a static characteristic. In this article, we present a strategy to chemically trigger dynamic topology changes in polymers in response to a specific chemical stimulus. Starting with a dimerized PEG and hydrophobic linear materials, a lightly cross-linked polymer, and a cross-linked hydrogel, transformations into an amphiphilic linear polymer, lightly cross-linked and linear random copolymers, a cross-linked polymer, and three different hydrogel matrices were achieved via two controllable cross-linking reactions: reversible conjugate additions and thiol-disulfide exchange. Significantly, all the polymers, before or after topological changes, can be triggered to degrade into thiol- or amine-terminated small molecules. The controllable transformations of polymeric morphologies and their degradation herald a new generation of smart materials.
AB - Polymer topology dictates dynamic and mechanical properties of materials. For most polymers, topology is a static characteristic. In this article, we present a strategy to chemically trigger dynamic topology changes in polymers in response to a specific chemical stimulus. Starting with a dimerized PEG and hydrophobic linear materials, a lightly cross-linked polymer, and a cross-linked hydrogel, transformations into an amphiphilic linear polymer, lightly cross-linked and linear random copolymers, a cross-linked polymer, and three different hydrogel matrices were achieved via two controllable cross-linking reactions: reversible conjugate additions and thiol-disulfide exchange. Significantly, all the polymers, before or after topological changes, can be triggered to degrade into thiol- or amine-terminated small molecules. The controllable transformations of polymeric morphologies and their degradation herald a new generation of smart materials.
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U2 - 10.1021/jacs.9b12122
DO - 10.1021/jacs.9b12122
M3 - Article
C2 - 32011873
AN - SCOPUS:85081011485
SN - 0002-7863
VL - 142
SP - 3913
EP - 3922
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 8
ER -