Childhood exposure to manganese and postural instability in children living near a ferromanganese refinery in Southeastern Ohio

Fedoria Rugless; Amit Bhattacharya; Paul Succop; Kim N. Dietrich; Cyndy Cox; Jody Alden; Pierce Kuhnell; Mary Barnas; Robert Wright; Patrick J. Parsons; Meredith L. Praamsma; Christopher D. Palmer; Caroline Beidler; Richard Wittberg; Erin N. Haynes

doi:10.1016/j.ntt.2013.12.005

Childhood exposure to manganese and postural instability in children living near a ferromanganese refinery in Southeastern Ohio

Fedoria Rugless, Amit Bhattacharya, Paul Succop, Kim N. Dietrich, Cyndy Cox, Jody Alden, Pierce Kuhnell, Mary Barnas, Robert Wright, Patrick J. Parsons, Meredith L. Praamsma, Christopher D. Palmer, Caroline Beidler, Richard Wittberg, Erin N. Haynes

Epidemiology & Environmental Health

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Airborne manganese (Mn) exposure can result in neurotoxicity and postural instability in occupationally exposed workers, yet few studies have explored the association ambient exposure to Mn in children and postural stability. The goal of this study was to determine the association between Mn and lead (Pb) exposure, as measured by blood Pb, blood and hair Mn and time weighted distance (TWD) from a ferromanganese refinery, and postural stability in children. A subset of children ages 7-9. years enrolled in the Marietta Community Actively Researching Exposure Study (CARES) were invited to participate. Postural balance was conducted on 55 children residing in Marietta, Ohio and the surrounding area. Samples of blood were collected and analyzed for Mn and Pb, and samples of hair were analyzed for Mn. Neuromotor performance was assessed using postural balance testing with a computer force platform system. Pearson correlations were calculated to identify key covariates. Associations between postural balance testing conditions and Mn and Pb exposure were estimated with linear regression analyses adjusting for gender, age, parent IQ, and parent age. Mean blood Mn was 10. μg/L (SEM. = 0.36), mean blood Pb was 0.85. μg/dL (SEM. = 0.05), and mean hair Mn was 0.76. μg/g (SEM. = 0.16). Mean residential distance from the refinery was 11.5. km (SEM. = 0.46). All three measures of Mn exposure were significantly associated with poor postural balance. In addition, low-level blood Pb was also negatively associated with balance outcomes. We conclude that Mn exposure and low-level blood Pb are significantly associated with poor postural balance.

Original language	English
Pages (from-to)	71-79
Number of pages	9
Journal	Neurotoxicology and Teratology
Volume	41
DOIs	https://doi.org/10.1016/j.ntt.2013.12.005
State	Published - Jan 2014

Bibliographical note

Funding Information:
This research study was supported by the National Institute of Environmental Health Sciences : 5T32ES10957 , R01ES016531 , R03 HD059615-01 , and P30-ES06096 . Support for this work was also received by an Institutional Clinical and Translational Science Award , NIH/NCRR 8UL1TR000077-04 . The authors would like to thank Dawn Wittberg, Marietta College for the use of their facilities to conduct the study, and the Marietta Community Actively Researching Exposure Community Advisory Board. This work was completed in partial fulfillment for the Doctor of Philosophy degree in Epidemiology in the Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine. All authors declare no actual or potential competing financial interests.

Keywords

Appalachian American
Children
Lead
Manganese
Postural balance

ASJC Scopus subject areas

Toxicology
Developmental Neuroscience
Cellular and Molecular Neuroscience

Access to Document

10.1016/j.ntt.2013.12.005

Cite this

Rugless, F., Bhattacharya, A., Succop, P., Dietrich, K. N., Cox, C., Alden, J., Kuhnell, P., Barnas, M., Wright, R., Parsons, P. J., Praamsma, M. L., Palmer, C. D., Beidler, C., Wittberg, R., & Haynes, E. N. (2014). Childhood exposure to manganese and postural instability in children living near a ferromanganese refinery in Southeastern Ohio. Neurotoxicology and Teratology, 41, 71-79. https://doi.org/10.1016/j.ntt.2013.12.005

@article{72dfd247a2934d7dac4f7447ae90bd03,

title = "Childhood exposure to manganese and postural instability in children living near a ferromanganese refinery in Southeastern Ohio",

abstract = "Airborne manganese (Mn) exposure can result in neurotoxicity and postural instability in occupationally exposed workers, yet few studies have explored the association ambient exposure to Mn in children and postural stability. The goal of this study was to determine the association between Mn and lead (Pb) exposure, as measured by blood Pb, blood and hair Mn and time weighted distance (TWD) from a ferromanganese refinery, and postural stability in children. A subset of children ages 7-9. years enrolled in the Marietta Community Actively Researching Exposure Study (CARES) were invited to participate. Postural balance was conducted on 55 children residing in Marietta, Ohio and the surrounding area. Samples of blood were collected and analyzed for Mn and Pb, and samples of hair were analyzed for Mn. Neuromotor performance was assessed using postural balance testing with a computer force platform system. Pearson correlations were calculated to identify key covariates. Associations between postural balance testing conditions and Mn and Pb exposure were estimated with linear regression analyses adjusting for gender, age, parent IQ, and parent age. Mean blood Mn was 10. μg/L (SEM. = 0.36), mean blood Pb was 0.85. μg/dL (SEM. = 0.05), and mean hair Mn was 0.76. μg/g (SEM. = 0.16). Mean residential distance from the refinery was 11.5. km (SEM. = 0.46). All three measures of Mn exposure were significantly associated with poor postural balance. In addition, low-level blood Pb was also negatively associated with balance outcomes. We conclude that Mn exposure and low-level blood Pb are significantly associated with poor postural balance.",

keywords = "Appalachian American, Children, Lead, Manganese, Postural balance",

author = "Fedoria Rugless and Amit Bhattacharya and Paul Succop and Dietrich, {Kim N.} and Cyndy Cox and Jody Alden and Pierce Kuhnell and Mary Barnas and Robert Wright and Parsons, {Patrick J.} and Praamsma, {Meredith L.} and Palmer, {Christopher D.} and Caroline Beidler and Richard Wittberg and Haynes, {Erin N.}",

note = "Funding Information: This research study was supported by the National Institute of Environmental Health Sciences : 5T32ES10957 , R01ES016531 , R03 HD059615-01 , and P30-ES06096 . Support for this work was also received by an Institutional Clinical and Translational Science Award , NIH/NCRR 8UL1TR000077-04 . The authors would like to thank Dawn Wittberg, Marietta College for the use of their facilities to conduct the study, and the Marietta Community Actively Researching Exposure Community Advisory Board. This work was completed in partial fulfillment for the Doctor of Philosophy degree in Epidemiology in the Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine. All authors declare no actual or potential competing financial interests.",

year = "2014",

month = jan,

doi = "10.1016/j.ntt.2013.12.005",

language = "English",

volume = "41",

pages = "71--79",

}

Rugless, F, Bhattacharya, A, Succop, P, Dietrich, KN, Cox, C, Alden, J, Kuhnell, P, Barnas, M, Wright, R, Parsons, PJ, Praamsma, ML, Palmer, CD, Beidler, C, Wittberg, R & Haynes, EN 2014, 'Childhood exposure to manganese and postural instability in children living near a ferromanganese refinery in Southeastern Ohio', Neurotoxicology and Teratology, vol. 41, pp. 71-79. https://doi.org/10.1016/j.ntt.2013.12.005

TY - JOUR

T1 - Childhood exposure to manganese and postural instability in children living near a ferromanganese refinery in Southeastern Ohio

AU - Rugless, Fedoria

AU - Bhattacharya, Amit

AU - Succop, Paul

AU - Dietrich, Kim N.

AU - Cox, Cyndy

AU - Alden, Jody

AU - Kuhnell, Pierce

AU - Barnas, Mary

AU - Wright, Robert

AU - Parsons, Patrick J.

AU - Praamsma, Meredith L.

AU - Palmer, Christopher D.

AU - Beidler, Caroline

AU - Wittberg, Richard

AU - Haynes, Erin N.

N1 - Funding Information: This research study was supported by the National Institute of Environmental Health Sciences : 5T32ES10957 , R01ES016531 , R03 HD059615-01 , and P30-ES06096 . Support for this work was also received by an Institutional Clinical and Translational Science Award , NIH/NCRR 8UL1TR000077-04 . The authors would like to thank Dawn Wittberg, Marietta College for the use of their facilities to conduct the study, and the Marietta Community Actively Researching Exposure Community Advisory Board. This work was completed in partial fulfillment for the Doctor of Philosophy degree in Epidemiology in the Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine. All authors declare no actual or potential competing financial interests.

PY - 2014/1

Y1 - 2014/1

N2 - Airborne manganese (Mn) exposure can result in neurotoxicity and postural instability in occupationally exposed workers, yet few studies have explored the association ambient exposure to Mn in children and postural stability. The goal of this study was to determine the association between Mn and lead (Pb) exposure, as measured by blood Pb, blood and hair Mn and time weighted distance (TWD) from a ferromanganese refinery, and postural stability in children. A subset of children ages 7-9. years enrolled in the Marietta Community Actively Researching Exposure Study (CARES) were invited to participate. Postural balance was conducted on 55 children residing in Marietta, Ohio and the surrounding area. Samples of blood were collected and analyzed for Mn and Pb, and samples of hair were analyzed for Mn. Neuromotor performance was assessed using postural balance testing with a computer force platform system. Pearson correlations were calculated to identify key covariates. Associations between postural balance testing conditions and Mn and Pb exposure were estimated with linear regression analyses adjusting for gender, age, parent IQ, and parent age. Mean blood Mn was 10. μg/L (SEM. = 0.36), mean blood Pb was 0.85. μg/dL (SEM. = 0.05), and mean hair Mn was 0.76. μg/g (SEM. = 0.16). Mean residential distance from the refinery was 11.5. km (SEM. = 0.46). All three measures of Mn exposure were significantly associated with poor postural balance. In addition, low-level blood Pb was also negatively associated with balance outcomes. We conclude that Mn exposure and low-level blood Pb are significantly associated with poor postural balance.

AB - Airborne manganese (Mn) exposure can result in neurotoxicity and postural instability in occupationally exposed workers, yet few studies have explored the association ambient exposure to Mn in children and postural stability. The goal of this study was to determine the association between Mn and lead (Pb) exposure, as measured by blood Pb, blood and hair Mn and time weighted distance (TWD) from a ferromanganese refinery, and postural stability in children. A subset of children ages 7-9. years enrolled in the Marietta Community Actively Researching Exposure Study (CARES) were invited to participate. Postural balance was conducted on 55 children residing in Marietta, Ohio and the surrounding area. Samples of blood were collected and analyzed for Mn and Pb, and samples of hair were analyzed for Mn. Neuromotor performance was assessed using postural balance testing with a computer force platform system. Pearson correlations were calculated to identify key covariates. Associations between postural balance testing conditions and Mn and Pb exposure were estimated with linear regression analyses adjusting for gender, age, parent IQ, and parent age. Mean blood Mn was 10. μg/L (SEM. = 0.36), mean blood Pb was 0.85. μg/dL (SEM. = 0.05), and mean hair Mn was 0.76. μg/g (SEM. = 0.16). Mean residential distance from the refinery was 11.5. km (SEM. = 0.46). All three measures of Mn exposure were significantly associated with poor postural balance. In addition, low-level blood Pb was also negatively associated with balance outcomes. We conclude that Mn exposure and low-level blood Pb are significantly associated with poor postural balance.

KW - Appalachian American

KW - Children

KW - Lead

KW - Manganese

KW - Postural balance

UR - http://www.scopus.com/inward/record.url?scp=84892390674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892390674&partnerID=8YFLogxK

U2 - 10.1016/j.ntt.2013.12.005

DO - 10.1016/j.ntt.2013.12.005

M3 - Article

C2 - 24370548

AN - SCOPUS:84892390674

SN - 0892-0362

VL - 41

SP - 71

EP - 79

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

ER -

Childhood exposure to manganese and postural instability in children living near a ferromanganese refinery in Southeastern Ohio

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this