Chiral gold(iii) complexes: speciation, in vitro, and in vivo anticancer profile

Adedamola S. Arojojoye, Jong H. Kim, Chibuzor Olelewe, Sean Parkin, Samuel G. Awuah

Research output: Contribution to journalArticlepeer-review

Abstract

Emerging synthetic development of chiral gold(iii) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine. Here, we demonstrate potential chemotherapeutic capability of [C^N]Au(iii)Cl(R-DuPhos) (1-7) complexes, containing 1,2-bis[(2R,5R)-2,5-dialkylphospholano]benzene, which shows good stabilty, potent anticancer activity, and tolerability in mice.

Original languageEnglish
Pages (from-to)10237-10240
Number of pages4
JournalChemical Communications
Volume58
Issue number73
DOIs
StatePublished - Aug 16 2022

Bibliographical note

Publisher Copyright:
© 2022 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry (all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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