Chiral gold(iii) complexes: speciation, in vitro, and in vivo anticancer profile

Adedamola S. Arojojoye; Jong H. Kim; Chibuzor Olelewe; Sean Parkin; Samuel G. Awuah

doi:10.1039/d2cc03081k

Chiral gold(iii) complexes: speciation, in vitro, and in vivo anticancer profile

Adedamola S. Arojojoye, Jong H. Kim, Chibuzor Olelewe, Sean Parkin, Samuel G. Awuah

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Emerging synthetic development of chiral gold(iii) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine. Here, we demonstrate potential chemotherapeutic capability of [C^N]Au(iii)Cl(R-DuPhos) (1-7) complexes, containing 1,2-bis[(2R,5R)-2,5-dialkylphospholano]benzene, which shows good stabilty, potent anticancer activity, and tolerability in mice.

Original language	English
Pages (from-to)	10237-10240
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	73
DOIs	https://doi.org/10.1039/d2cc03081k
State	Published - Aug 16 2022

Bibliographical note

Publisher Copyright:
© 2022 The Royal Society of Chemistry.

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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abstract = "Emerging synthetic development of chiral gold(iii) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine. Here, we demonstrate potential chemotherapeutic capability of [C\textasciicircum{}N]Au(iii)Cl(R-DuPhos) (1-7) complexes, containing 1,2-bis[(2R,5R)-2,5-dialkylphospholano]benzene, which shows good stabilty, potent anticancer activity, and tolerability in mice.",

author = "Arojojoye, \{Adedamola S.\} and Kim, \{Jong H.\} and Chibuzor Olelewe and Sean Parkin and Awuah, \{Samuel G.\}",

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T2 - speciation, in vitro, and in vivo anticancer profile

AU - Arojojoye, Adedamola S.

AU - Kim, Jong H.

AU - Olelewe, Chibuzor

AU - Parkin, Sean

AU - Awuah, Samuel G.

PY - 2022/8/16

Y1 - 2022/8/16

N2 - Emerging synthetic development of chiral gold(iii) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine. Here, we demonstrate potential chemotherapeutic capability of [C^N]Au(iii)Cl(R-DuPhos) (1-7) complexes, containing 1,2-bis[(2R,5R)-2,5-dialkylphospholano]benzene, which shows good stabilty, potent anticancer activity, and tolerability in mice.

AB - Emerging synthetic development of chiral gold(iii) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine. Here, we demonstrate potential chemotherapeutic capability of [C^N]Au(iii)Cl(R-DuPhos) (1-7) complexes, containing 1,2-bis[(2R,5R)-2,5-dialkylphospholano]benzene, which shows good stabilty, potent anticancer activity, and tolerability in mice.

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JO - Chemical Communications

JF - Chemical Communications

IS - 73

ER -

Chiral gold(iii) complexes: speciation, in vitro, and in vivo anticancer profile

Abstract

Bibliographical note

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