Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

David M. Armstrong, Gordon Bruce, Louis B. Hersh, Robert D. Terry

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.

Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalNeuroscience Letters
Issue number2
StatePublished - Nov 11 1986

Bibliographical note

Funding Information:
Supportedin part by NIH Grants AG05893 (L.B.H.), AG05344, a grant from the McKnight Foundation.


  • Alzheimer's disease
  • Choline acetyltransferase
  • Human
  • Immunocytochemistry
  • Neuritic plaque

ASJC Scopus subject areas

  • General Neuroscience


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