Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

David M. Armstrong; Gordon Bruce; Louis B. Hersh; Robert D. Terry

doi:10.1016/0304-3940(86)90564-1

Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

David M. Armstrong, Gordon Bruce, Louis B. Hersh, Robert D. Terry

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.

Original language	English
Pages (from-to)	229-234
Number of pages	6
Journal	Neuroscience Letters
Volume	71
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(86)90564-1
State	Published - Nov 11 1986

Bibliographical note

Funding Information:
Supportedin part by NIH Grants AG05893 (L.B.H.), AG05344, a grant from the McKnight Foundation.

Funding

Supportedin part by NIH Grants AG05893 (L.B.H.), AG05344, a grant from the McKnight Foundation.

Funders	Funder number
National Institutes of Health (NIH)	AG05344
National Institute on Aging	R55AG005893
McKnight Foundation

Keywords

Alzheimer's disease
Choline acetyltransferase
Human
Immunocytochemistry
Neuritic plaque

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3940(86)90564-1

Cite this

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abstract = "We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.",

keywords = "Alzheimer's disease, Choline acetyltransferase, Human, Immunocytochemistry, Neuritic plaque",

author = "Armstrong, {David M.} and Gordon Bruce and Hersh, {Louis B.} and Terry, {Robert D.}",

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doi = "10.1016/0304-3940(86)90564-1",

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AU - Bruce, Gordon

AU - Hersh, Louis B.

AU - Terry, Robert D.

N1 - Funding Information: Supportedin part by NIH Grants AG05893 (L.B.H.), AG05344, a grant from the McKnight Foundation.

PY - 1986/11/11

Y1 - 1986/11/11

N2 - We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.

AB - We have observed dystrophic choline acetyltransferase (ChAT)-positive processes surrounding the amyloid core of neuritic plaques in human neocortex, amygdala and hippocampus, using a polyclonal anti-human ChAT antiserum. These data, and those from studies of the aged monkey by other investigators, provide a morphologic counterpart for the biochemical abnormality of the cholinergic system in Alzheimer's disease and senile dementia of the Alzheimer type.

KW - Alzheimer's disease

KW - Choline acetyltransferase

KW - Human

KW - Immunocytochemistry

KW - Neuritic plaque

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Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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