Cholinergic influences on use-dependent plasticity

L. Sawaki, B. Boroojerdi, A. Kaelin-Lang, A. H. Burstein, C. M. Bütefisch, L. Kopylev, B. Davis, L. G. Cohen

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Motor practice elicits use-dependent plasticity in humans as well as in animals. Given the influence of cholinergic neurotransmission on learning and memory processes, we evaluated the effects of scopolamine (a muscarinic receptor antagonist) on use-dependent plasticity and corticomotor excitability in a double-blind placebo-controlled randomized design study. Use-dependent plasticity was substantially attenuated by scopolamine in the absence of global changes in corticomotor excitability. These results identify a facilitatory role for cholinergic influences in use-dependent plasticity in the human motor system.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalJournal of Neurophysiology
Issue number1
StatePublished - 2002

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology


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