Cholinergic influences on use-dependent plasticity

L. Sawaki; B. Boroojerdi; A. Kaelin-Lang; A. H. Burstein; C. M. Bütefisch; L. Kopylev; B. Davis; L. G. Cohen

doi:10.1152/jn.00279.2001

Cholinergic influences on use-dependent plasticity

L. Sawaki, B. Boroojerdi, A. Kaelin-Lang, A. H. Burstein, C. M. Bütefisch, L. Kopylev, B. Davis, L. G. Cohen

Neurology

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Motor practice elicits use-dependent plasticity in humans as well as in animals. Given the influence of cholinergic neurotransmission on learning and memory processes, we evaluated the effects of scopolamine (a muscarinic receptor antagonist) on use-dependent plasticity and corticomotor excitability in a double-blind placebo-controlled randomized design study. Use-dependent plasticity was substantially attenuated by scopolamine in the absence of global changes in corticomotor excitability. These results identify a facilitatory role for cholinergic influences in use-dependent plasticity in the human motor system.

Original language	English
Pages (from-to)	166-171
Number of pages	6
Journal	Journal of Neurophysiology
Volume	87
Issue number	1
DOIs	https://doi.org/10.1152/jn.00279.2001
State	Published - 2002

ASJC Scopus subject areas

General Neuroscience
Physiology

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10.1152/jn.00279.2001

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title = "Cholinergic influences on use-dependent plasticity",

abstract = "Motor practice elicits use-dependent plasticity in humans as well as in animals. Given the influence of cholinergic neurotransmission on learning and memory processes, we evaluated the effects of scopolamine (a muscarinic receptor antagonist) on use-dependent plasticity and corticomotor excitability in a double-blind placebo-controlled randomized design study. Use-dependent plasticity was substantially attenuated by scopolamine in the absence of global changes in corticomotor excitability. These results identify a facilitatory role for cholinergic influences in use-dependent plasticity in the human motor system.",

author = "L. Sawaki and B. Boroojerdi and A. Kaelin-Lang and Burstein, {A. H.} and B{\"u}tefisch, {C. M.} and L. Kopylev and B. Davis and Cohen, {L. G.}",

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AU - Sawaki, L.

AU - Boroojerdi, B.

AU - Kaelin-Lang, A.

AU - Burstein, A. H.

AU - Bütefisch, C. M.

AU - Kopylev, L.

AU - Davis, B.

AU - Cohen, L. G.

PY - 2002

Y1 - 2002

N2 - Motor practice elicits use-dependent plasticity in humans as well as in animals. Given the influence of cholinergic neurotransmission on learning and memory processes, we evaluated the effects of scopolamine (a muscarinic receptor antagonist) on use-dependent plasticity and corticomotor excitability in a double-blind placebo-controlled randomized design study. Use-dependent plasticity was substantially attenuated by scopolamine in the absence of global changes in corticomotor excitability. These results identify a facilitatory role for cholinergic influences in use-dependent plasticity in the human motor system.

AB - Motor practice elicits use-dependent plasticity in humans as well as in animals. Given the influence of cholinergic neurotransmission on learning and memory processes, we evaluated the effects of scopolamine (a muscarinic receptor antagonist) on use-dependent plasticity and corticomotor excitability in a double-blind placebo-controlled randomized design study. Use-dependent plasticity was substantially attenuated by scopolamine in the absence of global changes in corticomotor excitability. These results identify a facilitatory role for cholinergic influences in use-dependent plasticity in the human motor system.

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DO - 10.1152/jn.00279.2001

M3 - Article

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VL - 87

SP - 166

EP - 171

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

IS - 1

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Cholinergic influences on use-dependent plasticity

Abstract

ASJC Scopus subject areas

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