A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.
|Number of pages||7|
|State||Published - Feb 14 1986|
Bibliographical noteFunding Information:
We thank S. Price and R. DeMuth for excellentte chnicaal ssistancaen d K. Williams for typing the final manuscriptT.h is work was supportedb y PHS 5T32 NS-07195 (A.L.), PHS HD-04583, PHS NS-17661 and the McKnight Foundation (B.H.W.), the Brain ResearchF oundation( to the Universityo f Chicago, B.H.W.), PHS 5T32 GM-07281 (D.B.R.), NS-15739a nd AG-05893( L.B.H.).
- choline acetyltransferase
- cholinergic system
- cortical organization
ASJC Scopus subject areas
- Neuroscience (all)