Cholinergic innervation displays strikingly different laminar preferences in several cortical areas

A. Lysakowski; B. H. Wainer; D. B. Rye; G. Bruce; L. B. Hersh

doi:10.1016/0304-3940(86)90671-3

Cholinergic innervation displays strikingly different laminar preferences in several cortical areas

A. Lysakowski, B. H. Wainer, D. B. Rye, G. Bruce, L. B. Hersh

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.

Original language	English
Pages (from-to)	102-108
Number of pages	7
Journal	Neuroscience Letters
Volume	64
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(86)90671-3
State	Published - Feb 14 1986

Bibliographical note

Funding Information:
We thank S. Price and R. DeMuth for excellentte chnicaal ssistancaen d K. Williams for typing the final manuscriptT.h is work was supportedb y PHS 5T32 NS-07195 (A.L.), PHS HD-04583, PHS NS-17661 and the McKnight Foundation (B.H.W.), the Brain ResearchF oundation( to the Universityo f Chicago, B.H.W.), PHS 5T32 GM-07281 (D.B.R.), NS-15739a nd AG-05893( L.B.H.).

Keywords

acetylcholine
acetylcholinesterase
choline acetyltransferase
cholinergic system
cortical organization
rat

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0304-3940(86)90671-3

Cite this

@article{8d8dcf576b1a49d3891ff3e21164e367,

title = "Cholinergic innervation displays strikingly different laminar preferences in several cortical areas",

abstract = "A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.",

keywords = "acetylcholine, acetylcholinesterase, choline acetyltransferase, cholinergic system, cortical organization, rat",

author = "A. Lysakowski and Wainer, {B. H.} and Rye, {D. B.} and G. Bruce and Hersh, {L. B.}",

note = "Funding Information: We thank S. Price and R. DeMuth for excellentte chnicaal ssistancaen d K. Williams for typing the final manuscriptT.h is work was supportedb y PHS 5T32 NS-07195 (A.L.), PHS HD-04583, PHS NS-17661 and the McKnight Foundation (B.H.W.), the Brain ResearchF oundation( to the Universityo f Chicago, B.H.W.), PHS 5T32 GM-07281 (D.B.R.), NS-15739a nd AG-05893( L.B.H.).",

year = "1986",

month = feb,

day = "14",

doi = "10.1016/0304-3940(86)90671-3",

language = "English",

volume = "64",

pages = "102--108",

number = "1",

}

TY - JOUR

T1 - Cholinergic innervation displays strikingly different laminar preferences in several cortical areas

AU - Lysakowski, A.

AU - Wainer, B. H.

AU - Rye, D. B.

AU - Bruce, G.

AU - Hersh, L. B.

N1 - Funding Information: We thank S. Price and R. DeMuth for excellentte chnicaal ssistancaen d K. Williams for typing the final manuscriptT.h is work was supportedb y PHS 5T32 NS-07195 (A.L.), PHS HD-04583, PHS NS-17661 and the McKnight Foundation (B.H.W.), the Brain ResearchF oundation( to the Universityo f Chicago, B.H.W.), PHS 5T32 GM-07281 (D.B.R.), NS-15739a nd AG-05893( L.B.H.).

PY - 1986/2/14

Y1 - 1986/2/14

N2 - A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.

AB - A new rabbit polyclonal antiserum against choline acetyltransferase (ChAT) reveals that cholinergic innervation of the cortex varies strikingly among different cytoarchitecturally defined areas in the rat neocortex. These findings suggest that cholinergic transmission may be integrated differently into the local circuitries of various regions of the cerebral cortex. In addition, the pattern of staining observed with acetylcholinesterase histochemistry, which has been used for many years to demonstrate putative cholinergic fibers, only partially matches the staining pattern obtained with the more specific cholinergic marker, ChAT.

KW - acetylcholine

KW - acetylcholinesterase

KW - choline acetyltransferase

KW - cholinergic system

KW - cortical organization

KW - rat

UR - http://www.scopus.com/inward/record.url?scp=0022643524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022643524&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(86)90671-3

DO - 10.1016/0304-3940(86)90671-3

M3 - Article

C2 - 3008035

AN - SCOPUS:0022643524

SN - 0304-3940

VL - 64

SP - 102

EP - 108

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Cholinergic innervation displays strikingly different laminar preferences in several cortical areas

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this