TY - JOUR
T1 - Cholinergic innervation of the human cerebellum
AU - de Lacalle, Sonsoles
AU - Hersh, Louis B.
AU - Saper, Clifford B.
PY - 1993/2/15
Y1 - 1993/2/15
N2 - Cholinergic innervation of the human cerebellum was investigated immunocytochemically by using a polyclonal rabbit antiserum against choline acetyltransferase. Immunoreactive structures were found throughout the cerebellar cortex but were localized predominantly in the vermis, flocculus, and tonsilla. These included (1) a population of Golgi cells in the granular layer; (2) a subpopulation of mossy fibers and glomerular rosettes; (3) thin, varicose fibers closely associated with the Purkinje cell layer and the molecular layer; and (4) a relatively dense network of fibers and terminals contributing to the glomerular formations in the granular layer. In the cerebellar nuclei, some cells stained positively for choline acetyltransferase, and a terminal field pattern could be detected with a distinct but sparse network of varicose fibers. Acetylcholine appears to be a primary transmitter in the vestibulocerebellar pathways at several levels, which may account for the potent effects of muscarinic antagonists in diminishing vestibular vertigo in humans. © 1993 Wiley‐Liss, Inc.
AB - Cholinergic innervation of the human cerebellum was investigated immunocytochemically by using a polyclonal rabbit antiserum against choline acetyltransferase. Immunoreactive structures were found throughout the cerebellar cortex but were localized predominantly in the vermis, flocculus, and tonsilla. These included (1) a population of Golgi cells in the granular layer; (2) a subpopulation of mossy fibers and glomerular rosettes; (3) thin, varicose fibers closely associated with the Purkinje cell layer and the molecular layer; and (4) a relatively dense network of fibers and terminals contributing to the glomerular formations in the granular layer. In the cerebellar nuclei, some cells stained positively for choline acetyltransferase, and a terminal field pattern could be detected with a distinct but sparse network of varicose fibers. Acetylcholine appears to be a primary transmitter in the vestibulocerebellar pathways at several levels, which may account for the potent effects of muscarinic antagonists in diminishing vestibular vertigo in humans. © 1993 Wiley‐Liss, Inc.
KW - Golgi cells
KW - cerebellar cortex
KW - cerebellar nuclei
KW - immunohistochemistry
KW - mossy fiber
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U2 - 10.1002/cne.903280304
DO - 10.1002/cne.903280304
M3 - Article
C2 - 8440786
AN - SCOPUS:0027458421
SN - 0021-9967
VL - 328
SP - 364
EP - 376
JO - Journal of Comparative Neurology
JF - Journal of Comparative Neurology
IS - 3
ER -