Chromosome end maintenance by telomerase

Jennifer L. Osterhage, Katherine L. Friedman

Research output: Contribution to journalShort surveypeer-review

92 Scopus citations

Abstract

Telomeres, protein-DNA complexes at the ends of eukaryotic linear chromosomes, are essential for genome stability. The accumulation of chromosomal abnormalities in the absence of proper telomere function is implicated inhumanaging and cancer. Repetitive telomeric sequences are maintained by telomerase, a ribonucleoprotein complex containing a reverse transcriptase subunit, a template RNA, and accessory components. Telomere elongation is regulated at multiple levels, including assembly of the telomerase holoenzyme, recruitment of telomerase to the chromosome terminus, and telomere accessibility. This minireview provides an overview of telomerase structure, function, and regulation and the role of telomerase in human disease.

Original languageEnglish
Pages (from-to)16061-16065
Number of pages5
JournalJournal of Biological Chemistry
Volume284
Issue number24
DOIs
StatePublished - Jun 12 2009

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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