Chronic Δ9-tetrahydrocannabinol administration and schedule-induced aggression

D. R. Cherek; T. Thompson; T. Kelly

doi:10.1016/0091-3057(80)90374-3

Chronic Δ⁹-tetrahydrocannabinol administration and schedule-induced aggression

D. R. Cherek, T. Thompson, T. Kelly

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The effects of 0.5 mg/kg and 1.0 mg/kg of Δ⁹-tetrahydrocannabinol (Δ⁹-THC) on key-pecking maintained by a response-initiated fixed interval (FI) schedule of food presentation and schedule-induced aggression in the pigeon were studied. Initially, following the administration of Δ⁹-THC both the rate of key-pecking and attack responding were markedly reduced. Over sessions, tolerance developed to the suppressant effect on key-pecking, with the rate returning to the predrug level. The suppressing effect of Δ⁹-THC on the rate of attack remained at or near zero throughout the series of Δ⁹-THC injections.

Original language	English
Pages (from-to)	305-309
Number of pages	5
Journal	Pharmacology Biochemistry and Behavior
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(80)90374-3
State	Published - Feb 1980

Bibliographical note

Funding Information:
1The pyran numbering system for tetrahydrocannabinols was employed. Ag-tetrahydrocannabinol is equivalent to At-tetrahydrocannabinol using the monoterpenoid numbering system. ~This research was supported by USPHS grant MH-98565; manuscript preparation by grant DA-07097 and DA-07130. Reprints may be obtained from D. R. Cherek, Department of Psychiatry, L.S.U. Medical Center, P.O. Box 33932, Shreveport, LA 71130.

Keywords

Aggressive behavior
Chronic
Schedule-induced
Δ-tetrahydrocannabinol

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

Access to Document

10.1016/0091-3057(80)90374-3

Cite this

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title = "Chronic Δ9-tetrahydrocannabinol administration and schedule-induced aggression",

abstract = "The effects of 0.5 mg/kg and 1.0 mg/kg of Δ9-tetrahydrocannabinol (Δ9-THC) on key-pecking maintained by a response-initiated fixed interval (FI) schedule of food presentation and schedule-induced aggression in the pigeon were studied. Initially, following the administration of Δ9-THC both the rate of key-pecking and attack responding were markedly reduced. Over sessions, tolerance developed to the suppressant effect on key-pecking, with the rate returning to the predrug level. The suppressing effect of Δ9-THC on the rate of attack remained at or near zero throughout the series of Δ9-THC injections.",

keywords = "Aggressive behavior, Chronic, Schedule-induced, Δ-tetrahydrocannabinol",

author = "Cherek, {D. R.} and T. Thompson and T. Kelly",

note = "Funding Information: 1The pyran numbering system for tetrahydrocannabinols was employed. Ag-tetrahydrocannabinol is equivalent to At-tetrahydrocannabinol using the monoterpenoid numbering system. ~This research was supported by USPHS grant MH-98565; manuscript preparation by grant DA-07097 and DA-07130. Reprints may be obtained from D. R. Cherek, Department of Psychiatry, L.S.U. Medical Center, P.O. Box 33932, Shreveport, LA 71130.",

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AU - Cherek, D. R.

AU - Thompson, T.

AU - Kelly, T.

N1 - Funding Information: 1The pyran numbering system for tetrahydrocannabinols was employed. Ag-tetrahydrocannabinol is equivalent to At-tetrahydrocannabinol using the monoterpenoid numbering system. ~This research was supported by USPHS grant MH-98565; manuscript preparation by grant DA-07097 and DA-07130. Reprints may be obtained from D. R. Cherek, Department of Psychiatry, L.S.U. Medical Center, P.O. Box 33932, Shreveport, LA 71130.

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N2 - The effects of 0.5 mg/kg and 1.0 mg/kg of Δ9-tetrahydrocannabinol (Δ9-THC) on key-pecking maintained by a response-initiated fixed interval (FI) schedule of food presentation and schedule-induced aggression in the pigeon were studied. Initially, following the administration of Δ9-THC both the rate of key-pecking and attack responding were markedly reduced. Over sessions, tolerance developed to the suppressant effect on key-pecking, with the rate returning to the predrug level. The suppressing effect of Δ9-THC on the rate of attack remained at or near zero throughout the series of Δ9-THC injections.

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KW - Aggressive behavior

KW - Chronic

KW - Schedule-induced

KW - Δ-tetrahydrocannabinol

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