The effects of 0.5 mg/kg and 1.0 mg/kg of Δ9-tetrahydrocannabinol (Δ9-THC) on key-pecking maintained by a response-initiated fixed interval (FI) schedule of food presentation and schedule-induced aggression in the pigeon were studied. Initially, following the administration of Δ9-THC both the rate of key-pecking and attack responding were markedly reduced. Over sessions, tolerance developed to the suppressant effect on key-pecking, with the rate returning to the predrug level. The suppressing effect of Δ9-THC on the rate of attack remained at or near zero throughout the series of Δ9-THC injections.
|Number of pages||5|
|Journal||Pharmacology Biochemistry and Behavior|
|State||Published - Feb 1980|
Bibliographical noteFunding Information:
1The pyran numbering system for tetrahydrocannabinols was employed. Ag-tetrahydrocannabinol is equivalent to At-tetrahydrocannabinol using the monoterpenoid numbering system. ~This research was supported by USPHS grant MH-98565; manuscript preparation by grant DA-07097 and DA-07130. Reprints may be obtained from D. R. Cherek, Department of Psychiatry, L.S.U. Medical Center, P.O. Box 33932, Shreveport, LA 71130.
- Aggressive behavior
ASJC Scopus subject areas
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience