Chronic Δ9-tetrahydrocannabinol administration and schedule-induced aggression

D. R. Cherek, T. Thompson, T. Kelly

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The effects of 0.5 mg/kg and 1.0 mg/kg of Δ9-tetrahydrocannabinol (Δ9-THC) on key-pecking maintained by a response-initiated fixed interval (FI) schedule of food presentation and schedule-induced aggression in the pigeon were studied. Initially, following the administration of Δ9-THC both the rate of key-pecking and attack responding were markedly reduced. Over sessions, tolerance developed to the suppressant effect on key-pecking, with the rate returning to the predrug level. The suppressing effect of Δ9-THC on the rate of attack remained at or near zero throughout the series of Δ9-THC injections.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalPharmacology Biochemistry and Behavior
Issue number2
StatePublished - Feb 1980

Bibliographical note

Funding Information:
1The pyran numbering system for tetrahydrocannabinols was employed. Ag-tetrahydrocannabinol is equivalent to At-tetrahydrocannabinol using the monoterpenoid numbering system. ~This research was supported by USPHS grant MH-98565; manuscript preparation by grant DA-07097 and DA-07130. Reprints may be obtained from D. R. Cherek, Department of Psychiatry, L.S.U. Medical Center, P.O. Box 33932, Shreveport, LA 71130.


  • Aggressive behavior
  • Chronic
  • Schedule-induced
  • Δ-tetrahydrocannabinol

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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