Chronic kidney disease and stroke

Nada El Husseini, Omran Kaskar, Larry B. Goldstein

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Chronic kidney disease (CKD) is associated with an increased risk of both ischemic and hemorrhagic stroke. In addition to shared risk factors, this higher cerebrovascular risk is mediated by several CKD-associated mechanisms including platelet dysfunction, coagulation disorders, endothelial dysfunction, inflammation, and increased risk of atrial fibrillation. CKD can also modify the effect of treatments used in acute stroke and in secondary stroke prevention. We review the epidemiology and pathophysiology that link CKD and stroke and the impact of CKD on stroke outcomes. Interdisciplinary collaboration between nephrologists, pharmacists, hematologists, nutrition therapists, primary care physicians, and neurologists in providing care to these subjects may potentially improve outcomes.

Original languageEnglish
Pages (from-to)500-508
Number of pages9
JournalAdvances in Chronic Kidney Disease
Volume21
Issue number6
DOIs
StatePublished - 2014

Bibliographical note

Publisher Copyright:
© 2014 National Kidney Foundation, Inc.

Keywords

  • Alteplase
  • Chronic kidney disease
  • Stroke
  • Stroke prevention
  • Thrombolysis

ASJC Scopus subject areas

  • Nephrology

Fingerprint

Dive into the research topics of 'Chronic kidney disease and stroke'. Together they form a unique fingerprint.

Cite this