Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke

Candice M. Brown, Cheryl D. Bushnell, Gregory P. Samsa, Larry B. Goldstein, Carol A. Colton

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 weeks post-stroke compared to control individuals. Cases were African-Americans with lacunar stroke (n = 30), and controls were age-matched African-Americans with no history of stroke or other major neurologic disease (n = 37). Blood was obtained >6 weeks post-stroke and was analyzed for inflammatory biomarkers. Freshly isolated peripheral blood mononuclear cells were stimulated with lipopolysaccharide (LPS) to assess immune responsiveness in a subset of cases (n = 5) and controls (n = 4). After adjustment for covariates, the pro-inflammatory biomarkers, soluble vascular cadherin adhesion molecule-1 (sVCAM-1) and thrombin anti-thrombin (TAT), were independently associated with lacunar stroke. Immune responsiveness to LPS challenge was abnormal in cases compared to controls. African-Americans with lacunar stroke had elevated blood levels of VCAM-1 and TAT and an abnormal response to acute immune challenge >6 weeks post-stroke, suggesting a chronically compromised systemic inflammatory response.

Original languageEnglish
Pages (from-to)430-436
Number of pages7
JournalTranslational Stroke Research
Volume6
Issue number6
DOIs
StatePublished - Dec 1 2015

Bibliographical note

Publisher Copyright:
© 2015, Springer Science+Business Media New York.

Keywords

  • African-Americans
  • Biomarkers
  • Chronic inflammation
  • Lacunar stroke
  • Race-ethnic disparities
  • Small vessel disease

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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