Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats

Philip W. Landfield, Glen A. Morgan

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

One prediction of the hypothesis that the capacity for hippocampal frequency potentiation is relevant to behavioral plasticity is tested in this study, by chronically elevating magnesium in intact aged and young rats. Elevated extracellular Mg2+ specifically improves frequency potentiation in hippocampal slices, and chronic alterations in plasma Mg2+ can increase brain Mg2+ in intact animals. Aged and young rats on a diet that elevated plasma Mg2+ exhibited stronger frequency potentiation under urethane anesthesia, and showed improved maze reversal learning.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalBrain Research
Volume322
Issue number1
DOIs
StatePublished - Nov 19 1984

Keywords

  • aging
  • hippocampal frequency potentiation
  • maze reversal learning
  • plasma magnesium

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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