Circadian organization of the Gut Commensal Bacterium Klebsiella aerogenes

Kinga B. Graniczkowska, Vincent M. Cassone

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

While the expression of circadian rhythmicity is nearly universal among eukaryotic organisms, demonstration of this phenomenon in prokaryotes has been largely restricted to photosynthetic cyanobacteria until very recently. Growing interest in gastrointestinal microbiomes has revealed a complex temporal relationship between the clock of gastrointestinal track and the microbiome within. We have discovered that at least one member of the gut microbiome, Klebsiella (neé Enterobacter) aerogenes, responds to the indoleamine hormone melatonin, secreted by the gastrointestinal system itself, in a specific, dose-dependent fashion such that melatonin increases bacterial motility. Further research revealed that K. aerogenes also express a circadian rhythm in motility and gene expression that is temperature compensated if maintained in constant temperatures ranging from 27 °C to 40 °C. Although rhythmicity is unaltered by changes in constant temperature, cycles of ambient temperature entrain circadian clock in K. aerogenes. Circadian rhythms in these bacteria rapidly decrease in amplitude following exposure to temperature cycles. The mechanisms of this damping are discussed.

Original languageEnglish
Title of host publicationCircadian Rhythms in Bacteria and Microbiomes
Pages351-364
Number of pages14
ISBN (Electronic)9783030721589
DOIs
StatePublished - Jun 21 2021

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2021. All rights reserved.

Keywords

  • Gastrointestinal
  • Klebsiella aerogenes
  • Melatonin
  • Temperature
  • luxCDABE

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General Mathematics

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