Circadian rhythms from multiple oscillators: Lessons from diverse organisms

Deborah Bell-Pedersen; Vincent M. Cassone; David J. Earnest; Susan S. Golden; Paul E. Hardin; Terry L. Thomas; Mark J. Zoran

doi:10.1038/nrg1633

Circadian rhythms from multiple oscillators: Lessons from diverse organisms

Deborah Bell-Pedersen, Vincent M. Cassone, David J. Earnest, Susan S. Golden, Paul E. Hardin, Terry L. Thomas, Mark J. Zoran

Research output: Contribution to journal › Review article › peer-review

1149 Scopus citations

Abstract

The organization of biological activities into daily cycles is universal in organisms as diverse as cyanobacteria, fungi, algae, plants, flies, birds and man. Comparisons of circadian clocks in unicellular and multicellular organisms using molecular genetics and genomics have provided new insights into the mechanisms and complexity of clock systems. Whereas unicellular organisms require stand-alone clocks that can generate 24-hour rhythms for diverse processes, organisms with differentiated tissues can partition clock function to generate and coordinate different rhythms. In both cases, the temporal coordination of a multi-oscillator system is essential for producing robust circadian rhythms of gene expression and biological activity.

Original language	English
Pages (from-to)	544-556
Number of pages	13
Journal	Nature Reviews Genetics
Volume	6
Issue number	7
DOIs	https://doi.org/10.1038/nrg1633
State	Published - Jul 2005

Bibliographical note

Funding Information:
The authors are members of the Center for Research on Biological Clocks at Texas A&M University, Houston, USA. The work described in this review from the authors’ laboratories was funded by the US National Institutes of Health, including an NINDS Program Project Grant and an NIEHS Center Grant.

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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Cite this

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title = "Circadian rhythms from multiple oscillators: Lessons from diverse organisms",

abstract = "The organization of biological activities into daily cycles is universal in organisms as diverse as cyanobacteria, fungi, algae, plants, flies, birds and man. Comparisons of circadian clocks in unicellular and multicellular organisms using molecular genetics and genomics have provided new insights into the mechanisms and complexity of clock systems. Whereas unicellular organisms require stand-alone clocks that can generate 24-hour rhythms for diverse processes, organisms with differentiated tissues can partition clock function to generate and coordinate different rhythms. In both cases, the temporal coordination of a multi-oscillator system is essential for producing robust circadian rhythms of gene expression and biological activity.",

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note = "Funding Information: The authors are members of the Center for Research on Biological Clocks at Texas A&M University, Houston, USA. The work described in this review from the authors{\textquoteright} laboratories was funded by the US National Institutes of Health, including an NINDS Program Project Grant and an NIEHS Center Grant.",

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AU - Earnest, David J.

AU - Golden, Susan S.

AU - Hardin, Paul E.

AU - Thomas, Terry L.

AU - Zoran, Mark J.

N1 - Funding Information: The authors are members of the Center for Research on Biological Clocks at Texas A&M University, Houston, USA. The work described in this review from the authors’ laboratories was funded by the US National Institutes of Health, including an NINDS Program Project Grant and an NIEHS Center Grant.

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Circadian rhythms from multiple oscillators: Lessons from diverse organisms

Abstract

Bibliographical note

ASJC Scopus subject areas

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