Circadian rhythms of house sparrows are phase-shifted by pharmacological manipulation of brain serotonin

Vincent M. Cassone; Michael Menaker

doi:10.1007/BF00610675

Circadian rhythms of house sparrows are phase-shifted by pharmacological manipulation of brain serotonin

Vincent M. Cassone, Michael Menaker

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Fluoxetine, a specific serotonergic reuptake blocker and indirect agonist, and 5,6-dihydroxytryptamine, a serotonergic neurotoxin, affect the free-running locomotor rhythms of house sparrows, Passer domesticus. Both compounds caused phase-shifts in the circadian system that times locomotor activity of the birds. The magnitude and direction of the phase-shifts were dependent on the circadian phase of the drug administration, suggesting that serotonergic activity can modulate the circadian pacemaker of the house sparrow.

Original language	English
Pages (from-to)	145-152
Number of pages	8
Journal	Journal of Comparative Physiology A
Volume	156
Issue number	1
DOIs	https://doi.org/10.1007/BF00610675
State	Published - Jan 1985

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Physiology
Animal Science and Zoology
Behavioral Neuroscience

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10.1007/BF00610675

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title = "Circadian rhythms of house sparrows are phase-shifted by pharmacological manipulation of brain serotonin",

abstract = "Fluoxetine, a specific serotonergic reuptake blocker and indirect agonist, and 5,6-dihydroxytryptamine, a serotonergic neurotoxin, affect the free-running locomotor rhythms of house sparrows, Passer domesticus. Both compounds caused phase-shifts in the circadian system that times locomotor activity of the birds. The magnitude and direction of the phase-shifts were dependent on the circadian phase of the drug administration, suggesting that serotonergic activity can modulate the circadian pacemaker of the house sparrow.",

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AB - Fluoxetine, a specific serotonergic reuptake blocker and indirect agonist, and 5,6-dihydroxytryptamine, a serotonergic neurotoxin, affect the free-running locomotor rhythms of house sparrows, Passer domesticus. Both compounds caused phase-shifts in the circadian system that times locomotor activity of the birds. The magnitude and direction of the phase-shifts were dependent on the circadian phase of the drug administration, suggesting that serotonergic activity can modulate the circadian pacemaker of the house sparrow.

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Circadian rhythms of house sparrows are phase-shifted by pharmacological manipulation of brain serotonin

Abstract

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