The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the nondipping blood pressure in diabetes.
|Number of pages||7|
|Journal||Current Opinion in Pharmacology|
|State||Published - Apr 2021|
Bibliographical noteFunding Information:
The work from the authors' group cited in the review is supported by the US National Institute of Heart, Blood and Lung grants HL082791, HL106843, and HL141103 and American Diabetes Association 04-CD-04.
© 2021 Elsevier Ltd
- Blood pressure
- Smooth muscle
ASJC Scopus subject areas
- Drug Discovery