Circadian variations of vasoconstriction and blood pressure in physiology and diabetes

Tianfei Hou; Zhenheng Guo; Ming C. Gong

doi:10.1016/j.coph.2021.02.001

Circadian variations of vasoconstriction and blood pressure in physiology and diabetes

Tianfei Hou, Zhenheng Guo, Ming C. Gong

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the nondipping blood pressure in diabetes.

Original language	English
Pages (from-to)	125-131
Number of pages	7
Journal	Current Opinion in Pharmacology
Volume	57
DOIs	https://doi.org/10.1016/j.coph.2021.02.001
State	Published - Apr 2021

Bibliographical note

Funding Information:
The work from the authors' group cited in the review is supported by the US National Institute of Heart, Blood and Lung grants HL082791, HL106843, and HL141103 and American Diabetes Association 04-CD-04.

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

Blood pressure
Bmal1
Circadian
Clock
Diabetes
Smooth muscle
Vasoconstriction

ASJC Scopus subject areas

Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.coph.2021.02.001

Cite this

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title = "Circadian variations of vasoconstriction and blood pressure in physiology and diabetes",

abstract = "The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the nondipping blood pressure in diabetes.",

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AU - Guo, Zhenheng

AU - Gong, Ming C.

N1 - Funding Information: The work from the authors' group cited in the review is supported by the US National Institute of Heart, Blood and Lung grants HL082791, HL106843, and HL141103 and American Diabetes Association 04-CD-04. Publisher Copyright: © 2021 Elsevier Ltd

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AB - The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the nondipping blood pressure in diabetes.

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KW - Smooth muscle

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Circadian variations of vasoconstriction and blood pressure in physiology and diabetes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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