Circadian variations of vasoconstriction and blood pressure in physiology and diabetes

Tianfei Hou; Zhenheng Guo; Ming C. Gong

doi:10.1016/j.coph.2021.02.001

Circadian variations of vasoconstriction and blood pressure in physiology and diabetes

Tianfei Hou
, Zhenheng Guo
, Ming C. Gong

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the nondipping blood pressure in diabetes.

Original language	English
Pages (from-to)	125-131
Number of pages	7
Journal	Current Opinion in Pharmacology
Volume	57
DOIs	https://doi.org/10.1016/j.coph.2021.02.001
State	Published - Apr 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

Funding

The work from the authors' group cited in the review is supported by the US National Institute of Heart, Blood and Lung grants HL082791, HL106843, and HL141103 and American Diabetes Association 04-CD-04.

Funders	Funder number
American Diabetes Association Inc	04-CD-04
National Heart, Lung, and Blood Institute (NHLBI)	HL141103, HL106843, R01HL082791

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Blood pressure
Bmal1
Circadian
Clock
Diabetes
Smooth muscle
Vasoconstriction

ASJC Scopus subject areas

Pharmacology
Drug Discovery

Access to Document

10.1016/j.coph.2021.02.001

Cite this

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title = "Circadian variations of vasoconstriction and blood pressure in physiology and diabetes",

abstract = "The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the nondipping blood pressure in diabetes.",

keywords = "Blood pressure, Bmal1, Circadian, Clock, Diabetes, Smooth muscle, Vasoconstriction",

author = "Tianfei Hou and Zhenheng Guo and Gong, \{Ming C.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = apr,

doi = "10.1016/j.coph.2021.02.001",

language = "English",

volume = "57",

pages = "125--131",

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T1 - Circadian variations of vasoconstriction and blood pressure in physiology and diabetes

AU - Hou, Tianfei

AU - Guo, Zhenheng

AU - Gong, Ming C.

PY - 2021/4

Y1 - 2021/4

N2 - The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the nondipping blood pressure in diabetes.

AB - The intrinsic vascular smooth muscle contraction and vasoconstriction show time-of-day variations, contributing to the blood pressure circadian rhythm, which is essential for cardiovascular health. This brief review provides an overview of our current understanding of the mechanisms underlying the time-of-day variations of vascular smooth muscle contraction. We discuss the potential contribution of the time-of-day variations of vasoconstriction to the physiological blood pressure circadian rhythm. Finally, we survey the data obtained in the type 2 diabetic db/db mouse model that demonstrate the alterations of the time-of-day variations of vasoconstriction and the nondipping blood pressure in diabetes.

KW - Blood pressure

KW - Bmal1

KW - Circadian

KW - Clock

KW - Diabetes

KW - Smooth muscle

KW - Vasoconstriction

UR - https://www.scopus.com/pages/publications/85102346249

UR - https://www.scopus.com/pages/publications/85102346249#tab=citedBy

U2 - 10.1016/j.coph.2021.02.001

DO - 10.1016/j.coph.2021.02.001

M3 - Review article

C2 - 33721615

AN - SCOPUS:85102346249

SN - 1471-4892

VL - 57

SP - 125

EP - 131

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

ER -

Circadian variations of vasoconstriction and blood pressure in physiology and diabetes

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this