Circulating immune signatures across clinical stages of chronic pancreatitis: A pilot study

Rasmus Hagn-Meincke, Phil A. Hart, Dana K. Andersen, Santhi S. Vege, Evan L. Fogel, Jose Serrano, Melena D. Bellin, Mark D. Topazian, Darwin L. Conwell, Liang Li, Stephen K. Van Den Eeden, Asbjørn M. Drewes, Stephen J. Pandol, Chris E. Forsmark, William E. Fisher, Dhiraj Yadav, Søren S. Olesen, Walter G. Park

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective This pilot study seeks to identify serum immune signatures across clinical stages of patients with chronic pancreatitis (CP). Methods We performed a cross-sectional analysis of prospectively collected serum samples from the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translation StuDies-study. CP subjects were categorised into three clinical stages based on the presence/absence of metabolic complications: (1) CP with no diabetes and exocrine pancreatic dysfunction (EPD), (2) CP with either diabetes or EPD, and (3) CP with diabetes and EPD. Blinded samples were analysed using an 80-plex Luminex assay of cytokines/chemokines/adhesion molecules. Group and pairwise comparisons were performed to characterise immune signatures across CP subgroups. Results A total of 135 CP subjects (evenly distributed between clinical stages) and 50 controls were studied. Interleukin-6 (IL-6), interleukin-8 (IL-8), and soluble intercellular adhesion molecule 1 (sICAM-1) were significantly elevated in CP subjects compared to controls. The levels of IL-6 and IL-8 increased with advancing disease stages, with the highest levels observed in CP with diabetes and EPD (clinical stage 3). Furthermore, hepatocyte growth factor and macrophage-derived chemokine were significantly increased in clinical stage 3 compared to controls. Conclusion Our study reveals a progressive elevation in pro-inflammatory cytokines and chemokines with advancing clinical stages of CP. These findings indicate potential targets for the development of disease-modifying interventions.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number2
StatePublished - Feb 1 2024

Bibliographical note

Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.


  • chronic pancreatitis
  • immune signatures
  • metabolic complications

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Circulating immune signatures across clinical stages of chronic pancreatitis: A pilot study'. Together they form a unique fingerprint.

Cite this