Clarithromycin as an adjunct to one-stage full-mouth ultrasonic periodontal debridement in generalized aggressive periodontitis: A randomized controlled clinical trial

Naira Maria Rebelatto Bechara Andere, Nídia Cristina Castro Dos Santos, Cássia Fernandes Araujo, Ingrid Fernandes Mathias, Tiago Taiete, Renato Corrêa Viana Casarin, Maria Aparecida Neves Jardini, Luciana Machion Shaddox, Mauro Pedrine Santamaria

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background: The aim of the present study is to evaluate the periodontal clinical and microbiologic responses and possible adverse effects of clarithromycin (CLM) combined with periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis. Methods: Forty patients were selected and randomly assigned into one of two groups: 1) CLM (n = 20): onestage full-mouth ultrasonic debridement (FMUD) associated with CLM (500 mg, every 12 hours for 3 days); and 2) placebo (n = 20): FMUD associated with placebo pills. Clinical and microbiologic parameters were evaluated at baseline and 3 and 6 months postoperatively. Results: Both treatments presented statistically significant clinical and microbiologic improvements. However, the CLM group presented lower means of probing depth for pockets ≥ 7 mm at 6 months (4.0 ± 1.7 mm) compared with the placebo group (4.7 ± 1.3 mm) (P = 0.04). In addition, the CLM group also presented greater reduction of Porphyromonas gingivalis (Pg) DNA counts at 6 months (P = 0.0001). Conclusion: Results from this study suggest both treatments are effective; however, adjunct use of CLM to FMUD leads to better reduction of deep pockets and Pg at 6 months compared with FMUD alone.

Original languageEnglish
Pages (from-to)1244-1252
Number of pages9
JournalJournal of Periodontology
Volume88
Issue number12
DOIs
StatePublished - Dec 2017

Bibliographical note

Funding Information:
The authors appreciate the financial support provided by Research Funding Agency from São Paulo State (FAPESP), Brazil, Grants 2015/04621-5 and 2015/12669-8 and CNPq - National Council for Scientific and Technological Development (Grant # 301102/ 2016-3) for supporting Dr. Mauro P. Santamaria . The authors report no conflicts of interest related to this study.

Keywords

  • Aggressive periodontitis
  • Anti-infective agents
  • Clarithromycin
  • Microbiology
  • Periodontal debridement
  • Ultrasonics

ASJC Scopus subject areas

  • Periodontics

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