TY - JOUR
T1 - Class B scavenger receptors, caveolae and cholesterol homeostasis
AU - Graf, G. A.
AU - Matveev, S. V.
AU - Smart, E. J.
PY - 1999
Y1 - 1999
N2 - Class B scavenger receptors are predominately localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. Caveolae and their associated protein, caveolin, have been implicated in cholesterol trafficking and in the regulation of cellular cholesterol homeostasis. Recent studies indicate that scavenger receptor, class B, type I (SR-BI) mediates cholesterol flux between cells and lipoproteins. Caveolae appear to be the sites within the plasma membrane where such exchange occurs, suggesting that the regulation of caveolae and caveolins may be pivotal to the net flux of cholesterol between cells and lipoproteins when they are bound to SR-BI. (C) 2000, Elsevier Science Inc.
AB - Class B scavenger receptors are predominately localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae. Caveolae and their associated protein, caveolin, have been implicated in cholesterol trafficking and in the regulation of cellular cholesterol homeostasis. Recent studies indicate that scavenger receptor, class B, type I (SR-BI) mediates cholesterol flux between cells and lipoproteins. Caveolae appear to be the sites within the plasma membrane where such exchange occurs, suggesting that the regulation of caveolae and caveolins may be pivotal to the net flux of cholesterol between cells and lipoproteins when they are bound to SR-BI. (C) 2000, Elsevier Science Inc.
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U2 - 10.1016/S1050-1738(00)00031-1
DO - 10.1016/S1050-1738(00)00031-1
M3 - Review article
C2 - 11094329
AN - SCOPUS:0033295671
SN - 1050-1738
VL - 9
SP - 221
EP - 225
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 8
ER -