TY - JOUR
T1 - Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA)
T2 - Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy
AU - Carare, Roxana O.
AU - Aldea, Roxana
AU - Agarwal, Nivedita
AU - Bacskai, Brian J.
AU - Bechman, Ingo
AU - Boche, Delphine
AU - Bu, Guojun
AU - Bulters, Diederik
AU - Clemens, Alt
AU - Counts, Scott E.
AU - de Leon, Mony
AU - Eide, Per K.
AU - Fossati, Silvia
AU - Greenberg, Steven M.
AU - Hamel, Edith
AU - Hawkes, Cheryl A.
AU - Koronyo-Hamaoui, Maya
AU - Hainsworth, Atticus H.
AU - Holtzman, David
AU - Ihara, Masafumi
AU - Jefferson, Angela
AU - Kalaria, Raj N.
AU - Kipps, Christopher M.
AU - Kanninen, Katja M.
AU - Leinonen, Ville
AU - McLaurin, Jo Anne
AU - Miners, Scott
AU - Malm, Tarja
AU - Nicoll, James A.R.
AU - Piazza, Fabrizio
AU - Paul, Gesine
AU - Rich, Steven M.
AU - Saito, Satoshi
AU - Shih, Andy
AU - Scholtzova, Henrieta
AU - Snyder, Heather
AU - Snyder, Peter
AU - Thormodsson, Finnbogi Rutur
AU - van Veluw, Susanne J.
AU - Weller, Roy O.
AU - Werring, David J.
AU - Wilcock, Donna
AU - Wilson, Mark R.
AU - Zlokovic, Berislav V.
AU - Verma, Ajay
N1 - Publisher Copyright:
© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association
PY - 2020
Y1 - 2020
N2 - Two of the key functions of arteries in the brain are (1) the well-recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri-arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of Aβ plaques in the brain in Alzheimer's disease (AD) and deposition of Aβ within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of Aβ in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.
AB - Two of the key functions of arteries in the brain are (1) the well-recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble metabolites, such as amyloid beta (Aβ), from the brain and retina. As the brain and retina possess no conventional lymphatic vessels, fluid drainage toward peripheral lymph nodes is mediated via transport along basement membranes in the walls of capillaries and arteries that form the intramural peri-arterial drainage (IPAD) system. IPAD tends to fail as arteries age but the mechanisms underlying the failure are unclear. In some people this is reflected in the accumulation of Aβ plaques in the brain in Alzheimer's disease (AD) and deposition of Aβ within artery walls as cerebral amyloid angiopathy (CAA). Knowledge of the dynamics of IPAD and why it fails with age is essential for establishing diagnostic tests for the early stages of the disease and for devising therapies that promote the clearance of Aβ in the prevention and treatment of AD and CAA. This editorial is intended to introduce the rationale that has led to the establishment of the Clearance of Interstitial Fluid (ISF) and CSF (CLIC) group, within the Vascular Professional Interest Area of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment.
KW - IPAD
KW - ISTAART
KW - cerebrospinal fluid
KW - clearance
KW - interstitial fluid
UR - http://www.scopus.com/inward/record.url?scp=85096442319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096442319&partnerID=8YFLogxK
U2 - 10.1002/dad2.12053
DO - 10.1002/dad2.12053
M3 - Article
AN - SCOPUS:85096442319
VL - 12
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 1
M1 - e12053
ER -