TY - JOUR
T1 - Clinical aspects of ovarian pathology in the mare
AU - Troedsson, Mats H.T.
AU - McCue, Patrick M.
AU - Macpherson, Margo L.
PY - 2003
Y1 - 2003
N2 - Equine ovarian abnormalities can be divided for clinical purposes into abnormalities of follicular development, ovulation abnormalities, luteal dysfunction, ovarian tumors, and miscellaneous abnormalities. The objective of this review is to discuss specific causes of ovarian pathologies within these groups, their effect on fertility, diagnostics, and treatment options. It is concluded that ovarian abnormalities is a common cause of subfertility and infertility in the mare. Mares with abnormalities of ovarian follicular development caused by gonadal dysgenesis, advanced age, and equine Cushing's disease are generally more difficult to treat compared to mares with persistent anovulatory follicles, persistent corpus luteum, luteal insufficiency, or ovarian tumors. Recent data on the effect on follicular development following subcutaneous implantation of slow release GnRH agonist deslorelin acetate is discussed. It is concluded that deslorelin acetate can cause temporary down-regulation of FSH secretion with associated prolonged inter-ovulatory intervals. Removal of the implant following ovulation may circumvent this side effect. The use of testosterone and inhibin assays to accurately diagnose mares with granulosa-theca cell tumors (GTCT) is discussed, α-Inhibin, but not dimeric inhibin is elevated in approximately 90% single blood samples from mares with GTCT. Daily fluctuations in serum testosterone, makes a single blood samples analysis of this hormone less predictable for the tumor.
AB - Equine ovarian abnormalities can be divided for clinical purposes into abnormalities of follicular development, ovulation abnormalities, luteal dysfunction, ovarian tumors, and miscellaneous abnormalities. The objective of this review is to discuss specific causes of ovarian pathologies within these groups, their effect on fertility, diagnostics, and treatment options. It is concluded that ovarian abnormalities is a common cause of subfertility and infertility in the mare. Mares with abnormalities of ovarian follicular development caused by gonadal dysgenesis, advanced age, and equine Cushing's disease are generally more difficult to treat compared to mares with persistent anovulatory follicles, persistent corpus luteum, luteal insufficiency, or ovarian tumors. Recent data on the effect on follicular development following subcutaneous implantation of slow release GnRH agonist deslorelin acetate is discussed. It is concluded that deslorelin acetate can cause temporary down-regulation of FSH secretion with associated prolonged inter-ovulatory intervals. Removal of the implant following ovulation may circumvent this side effect. The use of testosterone and inhibin assays to accurately diagnose mares with granulosa-theca cell tumors (GTCT) is discussed, α-Inhibin, but not dimeric inhibin is elevated in approximately 90% single blood samples from mares with GTCT. Daily fluctuations in serum testosterone, makes a single blood samples analysis of this hormone less predictable for the tumor.
KW - Diagnosis
KW - Fertility
KW - Mare
KW - Ovarian disorders
KW - Treatment
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U2 - 10.21836/pem20030601
DO - 10.21836/pem20030601
M3 - Article
AN - SCOPUS:0344584878
SN - 0177-7726
VL - 19
SP - 577
EP - 584
JO - Pferdeheilkunde
JF - Pferdeheilkunde
IS - 6
ER -