Clinical Outcome of Takotsubo Cardiomyopathy Diagnosed With or Without Coronary Angiography

Naoki Misumida, Gbolahan O. Ogunbayo, Sun Moon Kim, Ahmed Abdel-Latif, Khaled M. Ziada, Vincent L. Sorrell

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Takotsubo cardiomyopathy (TC) is definitively diagnosed following the exclusion of acute coronary syndrome. We aimed to examine the rate of coronary angiography in patients diagnosed with TC and also the outcome of patients with TC diagnosed with or without coronary angiography. We analyzed the National Inpatient Sample database from 2010 to 2014 and identified patients hospitalized with a primary diagnosis of TC. We compared in-hospital mortality between patients who underwent coronary angiography and those who did not. We also evaluated the association between coronary angiography and in-hospital mortality using a propensity score–adjusted multivariable analysis. Among 22 818 patients diagnosed with TC, 87.4% underwent coronary angiography and 12.6% did not. Patients who did not undergo coronary angiography had a higher in-hospital mortality than those who did (3.0% vs 0.9%; P <.001). Increased mortality in patients who did not undergo coronary angiogram was observed in both male (8.0% vs 2.8%; P =.03) and female patients (2.6% vs 0.7%; P <.001) and in patients 61 to 80 years old and ≥81 years old, but not in patients ≤60 years old. Multivariable analysis demonstrated that the lack of coronary angiography was independently associated with higher in-hospital mortality (adjusted odds ratio: 2.92; 95% confidence interval: 1.52-5.65; P =.001).

Original languageEnglish
Pages (from-to)56-61
Number of pages6
Issue number1
StatePublished - Jan 1 2019

Bibliographical note

Publisher Copyright:
© The Author(s) 2018.


  • acute coronary syndrome
  • apical ballooning syndrome
  • coronary angiography
  • stress-induced cardiomyopathy
  • takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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