Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy

Jacob T. Brown; Jeffrey R. Bishop; Katrin Sangkuhl; Erika L. Nurmi; Daniel J. Mueller; Jean C Dinh; Andrea Gaedigk; Teri E. Klein; Kelly E. Caudle; James T. McCracken; Jose de Leon; J.  Steven Leeder

doi:10.1002/cpt.1409

Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy

Jacob T. Brown, Jeffrey R. Bishop, Katrin Sangkuhl, Erika L. Nurmi, Daniel J. Mueller, Jean C Dinh, Andrea Gaedigk, Teri E. Klein, Kelly E. Caudle, James T. McCracken, Jose de Leon, J. Steven Leeder

Research output: Contribution to journal › Review article › peer-review

166 Scopus citations

Abstract

Atomoxetine is a nonstimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD). Cytochrome P450 (CYP)2D6 polymorphisms influence the metabolism of atomoxetine thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for atomoxetine based on CYP2D6 genotype (updates at www.cpicpgx.org).

Original language	English
Pages (from-to)	94-102
Number of pages	9
Journal	Clinical Pharmacology and Therapeutics
Volume	106
Issue number	1
DOIs	https://doi.org/10.1002/cpt.1409
State	Published - Jul 2019

Bibliographical note

Publisher Copyright:
© 2019 The Authors Clinical Pharmacology & Therapeutics © 2019 American Society for Clinical Pharmacology and Therapeutics

Funding

This work was funded by the National Institutes of Health (NIH) for CPIC (R24GM115264; U24HG010135-01) and PharmGKB (R24GM61374), PharmVar (R24GM123930). Atomoxetine studies conducted by the authors (J.T.B., A.G., J.C.D., and J.S.L.) have been supported by R01HD058556 and U54HD090258.

Funders	Funder number
National Institutes of Health (NIH)	R24GM123930, U54HD090258, R24GM61374, U24HG010135-01, R24GM115264
National Institutes of Health (NIH)
NIH National Institute of Child Health and Human Development National Center for Medical Rehabilitation Research	R01HD058556
NIH National Institute of Child Health and Human Development National Center for Medical Rehabilitation Research

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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Brown, J. T., Bishop, J. R., Sangkuhl, K., Nurmi, E. L., Mueller, D. J., Dinh, JC., Gaedigk, A., Klein, T. E., Caudle, K. E., McCracken, J. T., de Leon, J., & Leeder, J. S. (2019). Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy. Clinical Pharmacology and Therapeutics, 106(1), 94-102. https://doi.org/10.1002/cpt.1409

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abstract = "Atomoxetine is a nonstimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD). Cytochrome P450 (CYP)2D6 polymorphisms influence the metabolism of atomoxetine thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for atomoxetine based on CYP2D6 genotype (updates at www.cpicpgx.org).",

author = "Brown, \{Jacob T.\} and Bishop, \{Jeffrey R.\} and Katrin Sangkuhl and Nurmi, \{Erika L.\} and Mueller, \{Daniel J.\} and Jean C Dinh and Andrea Gaedigk and Klein, \{Teri E.\} and Caudle, \{Kelly E.\} and McCracken, \{James T.\} and \{de Leon\}, Jose and Leeder, \{J. Steven\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors Clinical Pharmacology \& Therapeutics {\textcopyright} 2019 American Society for Clinical Pharmacology and Therapeutics",

year = "2019",

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doi = "10.1002/cpt.1409",

language = "English",

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Brown, JT, Bishop, JR, Sangkuhl, K, Nurmi, EL, Mueller, DJ, Dinh, JC, Gaedigk, A, Klein, TE, Caudle, KE, McCracken, JT, de Leon, J & Leeder, JS 2019, 'Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy', Clinical Pharmacology and Therapeutics, vol. 106, no. 1, pp. 94-102. https://doi.org/10.1002/cpt.1409

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T1 - Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy

AU - Brown, Jacob T.

AU - Bishop, Jeffrey R.

AU - Sangkuhl, Katrin

AU - Nurmi, Erika L.

AU - Mueller, Daniel J.

AU - Dinh, Jean C

AU - Gaedigk, Andrea

AU - Klein, Teri E.

AU - Caudle, Kelly E.

AU - McCracken, James T.

AU - de Leon, Jose

AU - Leeder, J. Steven

PY - 2019/7

Y1 - 2019/7

N2 - Atomoxetine is a nonstimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD). Cytochrome P450 (CYP)2D6 polymorphisms influence the metabolism of atomoxetine thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for atomoxetine based on CYP2D6 genotype (updates at www.cpicpgx.org).

AB - Atomoxetine is a nonstimulant medication used to treat attention-deficit/hyperactivity disorder (ADHD). Cytochrome P450 (CYP)2D6 polymorphisms influence the metabolism of atomoxetine thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for atomoxetine based on CYP2D6 genotype (updates at www.cpicpgx.org).

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Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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