Clinical presentation, histology, and treatment in 430 patients with primary tumors of the spinal cord, spinal meninges, or cauda equina: Clinical article

Herbert H. Engelhard, J. Lee Villano, Kimberly R. Porter, Andrew K. Stewart, Manali Barua, Fred G. Barker, Herbert B. Newton

Research output: Contribution to journalArticlepeer-review

166 Scopus citations

Abstract

Object. Patients having a primary tumor of the spinal cord, spinal meninges or cauda equina, are relatively rare. Neurosurgeons encounter and treat such patients, and need to be aware of their clinical presentation, tumor types, treatment options, and potential complications. The purpose of this paper is to report results from a series of 430 patients with primary intraspinal tumors, taken from a larger cohort of 9661 patients with primary tumors of the CNS. Methods. Extensive information on individuals diagnosed (in the year 2000) as having a primary CNS neoplasm was prospectively collected in a Patient Care Evaluation Study conducted by the Commission on Cancer of the American College of Surgeons. Data from US hospital cancer registries were submitted directly to the National Cancer Database. Intraspinal tumor cases were identified based on ICD-O-2 topography codes C70.1, C72.0, and C72.1. Analyses were performed using SPSS. Results. Patients with primary intraspinal tumors represented 4.5% of the CNS tumor group, and had a mean age of 49.3 years. Pain was the most common presenting symptom, while the most common tumor types were meningioma (24.4%), ependymoma (23.7%), and schwannoma (21.2%). Resection, surgical biopsy, or both were performed in 89.3% of cases. Complications were low, but included neurological worsening (2.2%) and infection (1.6%). Radiation therapy and chemotherapy were administered to 20.3% and 5.6% of patients, respectively. Conclusions. Data from this study are suitable for benchmarking, describing prevailing patterns of care, and generating additional hypotheses for future studies.

Original languageEnglish
Pages (from-to)67-77
Number of pages11
JournalJournal of Neurosurgery: Spine
Volume13
Issue number1
DOIs
StatePublished - Jul 2010

Keywords

  • Cancer registry
  • Cauda equina
  • Epidemiology
  • Karnofsky performance scale
  • Spinal cord tumor
  • Spinal neoplasm

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology

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